Results 181 to 190 of about 22,287,702 (258)

Integrated Electrode-to-Device Design via Combination of Grain Boundary Reconstruction and Dynamic Gas Management Toward Stable 3 Ah Aqueous Zinc-Iodine Pouch Cells. [PDF]

Adv Mater
Zhang M, Sun R, Mo H, Sun C, Lin H, Jiang H, Zhao J, Yang Y.   +7 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Risk Factors for Pouch Neoplasia in Patients With Inflammatory Bowel Disease: A Case-Control Study. [PDF]

Gastro Hep Adv
Wang S, Ko HM, Lukin DJ, Bertucci Zoccali M, Ahmed Ali U, Kiran RP, Scherl EJ, Shen B.   +7 more
europepmc   +1 more source

Lithium‐Ion Battery Safety Evaluation by Quantifying Lithium Plating Degree Based on Pressure Signals

Advanced Science, EarlyView.
Low N/P cells enable controllable lithium plating, allowing the lithium plating degree (DLi) to be quantified and linked to thermal safety. Pressure signals during calibration provide a non‐destructive route to diagnose DLi, while thermal response tests define safety levels and management strategies. The framework remains applicable in commercial 12 Ah
Haonan Liu, Jiangong Zhu, Wenyuan Weng, Bin Shen, Wenjun Fan, Yang Wang, Huapeng Lu, Wuliyasu He, Chunjing Lin, Xuezhe Wei, Haifeng Dai   +10 more
wiley   +1 more source

Constructing zero-external-pressure high-performance sulfide all-solid-state pouch cells via asymmetric interfacial electrophilicity. [PDF]

Sci Adv
Liu T, Wang T, Fang Z, Jiang X, Zhou D, Liu X.   +5 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Accelerating the decomposition kinetics of Li₅FeO₄ for mitigating potential risks in practical applications. [PDF]

Chem Sci
Li L, Xie H, Zheng Y, Li Q, Chen Y, Tian Y, Zou Y, Sun H, Zhu Y, Li L, Yin J, Zhang K, Wu G, Zeng J, Bao J, Yang M, Ye Y, Sun X, Sun Y, Qiao Y, Sun SG.   +20 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Synergistic interfacial-mechanical binder design for high-areal-capacity and long-lifespan Si-based negative electrodes in practical pouch cells. [PDF]

Nat Commun
Li Z, Wu Z, Qian S, Lv X, Dai C, Lin Z, Zheng M, Liu T, Song TL, Lin Z, Lu J.   +10 more
europepmc   +1 more source