Results 201 to 210 of about 22,287,702 (258)

Bond Exchange-Driven Interfacial Relay Redox Enables Ultrahigh-Rate Zn Batteries With High Iodine Utilization. [PDF]

Angew Chem Int Ed Engl
Qi J, Zheng F, Shi Z, Huang H, Liu G, Ye M, Du W, Zhang Y, Wen Z, Liu X, Ma L, Wei Y, Tang Y, Li CC.   +13 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Unlocking Interfacial Binder Chemistry for Efficient Li⁺ Desolvation in 3C-Rate Lithium Metal Pouch Cells. [PDF]

Angew Chem Int Ed Engl
Huang H, Liao J, Wang X, Dong Q, Zhang J, Hou Y, Li J, Xie J, Guo H, Han X, Hu W.   +10 more
europepmc   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Unlocking an All-Anisotropic-Component Integrated Paradigm Toward Practical Solid-State Zinc Metal Pouch Cells. [PDF]

Angew Chem Int Ed Engl
Ma D, Yang X, Yang M, Zhu J, He Y, He L, Ouyang K, Wang Y, Mi H, Zhang P.   +9 more
europepmc   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Intramolecular charge redistribution of phosphate anions enabling ultrahigh-voltage lithium metal battery of 600 Wh kg^-1. [PDF]

Sci Adv
Zhang S, Meng F, Yang L, Liu H, Du X, Zhuang X, Xie B, Wang S, Qiao L, Ma J, Dong S, Chang CK, Chuang YC, Kuo CY, Chen CT, Hu Z, Cui Z, Xu G, Cui G.   +18 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source