Results 71 to 80 of about 2,860,718 (307)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

High Pressure Elastic Behavior of Synthetic Mg3Y2(SiO4)3 Garnet up to 9 GPa

Advances in Materials Science and Engineering, 2013
The compression behavior of synthetic magnesium- (Mg-) yttrium (Y) garnet Mg3Y2(SiO4)3 has been investigated upto about 8.79 GPa at 300 K using in situ angle-dispersive X-ray diffraction and a diamond anvil cell at the beamline X17C, National Synchrotron
Dawei Fan, Maining Ma, Shuyi Wei, Zhiqiang Chen, Hongsen Xie   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pressure-induced changes of the vibrational modes of spin-crossover complexes studied by nuclear resonance scattering of synchrotron radiation

, 2012
Nuclear inelastic scattering (NIS) spectra were recorded for the spin-crossover complexes STP and ETP (STP = [Fe(1,1,1-trisf[N-(2-pyridylmethyl)-N-methylamino]methylg- ethane)](ClO4)2 and ETP = [Fe(1,1,1-trisf[N-(2-pyridylmethyl)-N-methylamino]methylg ...
Chumakov, A. I., Giefers, H., Leupold, O., Paulsen, H., Toftlund, H., Trautwein, A. X., Winkler, H., Wolny, J. A., Wortmann, G.   +8 more
core   +1 more source

Unexpected Semimetallic BiS₂ at High Pressure and High Temperature [PDF]

The Journal of Physical Chemistry Letters, 2018
In the past decade, the group V-VI compounds have been widely investigated due to their excellent properties and applications. It is now accepted that diverse stoichiometry can yield new compounds with unanticipated properties, uncovering potentially new physicochemical mechanisms. However, in this group, aside from the conventional A2B3-type, no other
Liu, Guangtao, Yu, Zhenhai, Liu, Hanyu, Redfern, Simon AT, Feng, Xiaolei, Li, Xin, Yuan, Ye, Yang, Ke, Hirao, Naohisa, Kawaguchi, Saori Imada, Li, Xiaodong, Wang, Lin, Ma, Yanming   +12 more
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crystal structure of solid Oxygen at high pressure and low temperature

, 2001
Results of X-ray diffraction experiments on solid oxygen at low temperature and at pressures up to 10 GPa are presented.A careful sample preparation and annealing around 240 K allowed to obtain very good diffraction patterns in the orthorhombic delta ...
A.P. Hammersley, C.A. English, D. Schiferl, D. Schiferl, D.R. Ragan, E.M. Hörl, F.A Gorelli, F.A. Gorelli, Federico A. Gorelli, H. d’Amour, H.J. Jodl, H.K. Mao, J. Yen, Lorenzo Ulivi, M. Nicol, M. Santoro, Mario Santoro, Michael Hanfland, R. LeSar, R.A. Alikhanov, R.D. Etters, R.J. Meier, S. Desgreniers, S.W. Johnson, Y. Akahama   +24 more
core   +1 more source

Direct evidence for the emergence of a pressure induced nodal superconducting gap in the iron-based superconductor Ba_0.65Rb_0.35Fe_2As_2 [PDF]

, 2015
Identifying the superconducting (SC) gap structure of the iron-based high-temperature superconductors (Fe-HTS's) remains a key issue for the understanding of superconductivity in these materials.
Amato, Alex, Biswas, Pabitra Kumar, Bukowski, Zbigniew, Fernandes, Rafael, Guguchia, Zurab, Kang, Jian, Keller, Hugo, Khasanov, Rustem, Luetkens, Hubertus, Morenzoni, Elvezio, Prando, Giacomo, Shengelaya, Alexander, von Rohr, Fabian   +12 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effects of high temperature and pressure on silica optical fibre sensors

, 1998
We report on the effects of liquids at high temperature and pressure on silica optical fibres, sensors and gratings. We propose that the diffusion of molecules into the silica and the resultant expansion of the network are responsible for observed fibre ...
Clowes, J.R., McInnes, J., Payne, D.N., Zervas, M.N.   +3 more
core   +1 more source