Results 51 to 60 of about 510,944 (265)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cavitation upon low-speed solid–liquid impact
Nature Communications, 2021 A solid hitting a liquid surface normally creates a region of high pressure at the solid-liquid contact area. Now, it is shown that for a flat-bottomed cylinder hitting a liquid at low-enough impact speed, the local pressure is sufficiently low to cause ...
Nathan B. Speirs +4 more
doaj +1 more source
High-pressure structural changes in liquid silica [PDF]
Physical Review E, 2016 The structural properties of liquid silica at high pressure and moderate temperature conditions, also referred to as the warm dense matter regime, were investigated using time-resolved K-edge x-ray absorption spectroscopy and ab initio calculations. We used a nanosecond laser beam to compress uniformly a solid SiO_{2} target and a picosecond laser beam
Denoeud, A. +7 more
openaire +3 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Random Packing Modelling under High Pressure for Gas-Liquid Systems
Chemical Engineering Transactions, 2018 This work presents a design principle for the prediction of the separation efficiency of random, non-perforated and lattice-type, packing with different size and type for gas-liquid systems under high pressure up to 90 bar for distillation and absorption
Jerzy Mackowiak
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
High Frequency Liquid Sinusoidal Pressure Calibration Based on Laser Interferometry
工程科学与技术, 2020 A large number of dynamic pressure sensors are used to evaluate and test in the development of equipment and engineering application. In order to improve measurement accuracy and data reliability and solve the problem of traceability of amplitude ...
Bo LI +5 more
doaj
Energies, 2019 As environmental requirements become more stringent, the liquid carbon dioxide blasting system is one of the non-explosive blasting technologies that, with low tensile stress energy, will replace the chemical explosive blasting technology, and the impact
Bo Ke +4 more
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source