Results 51 to 60 of about 461,642 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE) [PDF]

, 2014
This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrine disruptors, biocides, polycyclic aromatic ...
Arbulu, Azzouz, Barco-Bonilla, Buchholz, Cacho, Camino-Sánchez, Canellas, de Sousa, Domeño, Eduardo González-Mazo, Esteve-Turrillas, Gago-Ferrero, Gomez, Jaspers, Johnsen, Kataoka, Kawaguchi, Kawaguchi, Krüger, Kumirska, Liu, Machado, Magi, Marina G. Pintado-Herrera, Negreira, Ochiai, O′Toole, Pablo A. Lara-Martín, Pintado-Herrera, Pintado-Herrera, Portolés, Prieto, Pérez-Carrera, Quintana, Ramírez, Rodil, Sampedro, Sanchez-Ortega, Stevens   +38 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Evidence of late Quaternary environmental change in a continental east Antarctic lake from lacustrine sedimentary pigment distributions [PDF]

, 2005
A sediment core from Progress Lake, one of the oldest lacustrine sequences in East Antarctica, contains distinct zones dating from a previous interglacial (most likely Marine Isotope Stage 5e, c.
Hodgson, D A, Keely, B J, Squier, A H
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Screening tests of tannins in overground organs of Zea mays L.

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. The introduction of new hemostatic drugs is a modern question. Using of tannins is promising especially for this segment of Pharmacy, as they are able to stop the bleeding.
U. V. Karpiuk, V. S. Kislichenko, I. S. Cholak, O. I. Yemelianova   +3 more
doaj   +1 more source

The edoxaban‐M4 metabolite and measurement of edoxaban by chromogenic assays in human plasma

Research and Practice in Thrombosis and Haemostasis, 2022
Introduction Edoxaban is the only anti‐Xa inhibitor metabolized in pharmacologically active moiety that could interfere with chromogenic anti‐Xa assays, especially in case of drug‐drug interactions or physiological disorders.
Romain Siriez, Halil Yildiz, Céline Bouvy, Hélène Haguet, Vincent Maloteau, Michaël Hardy, François Mullier, Jean‐Michel Dogné, Philippe Hainaut, Jonathan Douxfils   +9 more
doaj   +1 more source

Apple scab control with grapefruit seed extract: no alternative to chemical fungicides [PDF]

, 2004
The growth inhibiting effect of four commercially available grapefruit seed extracts on the causal organism of apple scab Venturia inaequalis was tested.
Kelderer, Markus, Marschall, Klaus, Spitaler, Renate, Stuppner, Hermann, Zelger, Roland, Zidorn, Christian   +5 more
core  

PEO/CHCl3: Crystallinity of the polymer and vapor pressure of the solvent - Equilibrium and non-equilibrium phenomena - [PDF]

, 2003
Vapor pressures were measured for the system chloroform/polyethylene oxide (peo, weight average molar mass = 1000 kg/mol) at 25 degrees centigrade as a function of the weight fraction w of the polymer by means of a combination of head space sampling and ...
KHassanova, A., Wolf, B. A.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source