Results 231 to 240 of about 35,372,359 (291)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

How to achieve high-quality development of SRDI enterprises-A study of the TOE framework-based configuration. [PDF]

PLoS One
Zhang Z, Feng H, Wang L, Yang L.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Identification method and application of order parameters for organizational systems considering time-series values: A case study on high-quality development in China's regional manufacturing industry. [PDF]

PLoS One
Wen X, Zhou Y.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Policy optimization for high-quality development and openness of China's healthcare sector: a tripartite evolutionary game based on wholly foreign-owned hospitals, public hospitals and the government. [PDF]

Front Public Health
Xiao L, Qingjin W, Hao G, Shan J.
europepmc   +1 more source

Ecological niche measurement and high-quality development of "the Belt and Road" core area. [PDF]

PLoS One
Zhang H, Abdusuli N.
europepmc   +1 more source

Exploring high quality development of animal husbandry in Qinghai province from the perspective of the Tibetan sheep industry. [PDF]

Sci Rep
Luo G, Cui J.
europepmc   +1 more source

A pathway towards high-quality development of the manufacturing industry: Does scientific and technological talent matter? [PDF]

PLoS One
Li D, Yao Q.
europepmc   +1 more source

Evaluating the impact of technological development policy on the high-quality development of the manufacturing industry: Mechanisms and threshold effects. [PDF]

Heliyon
Yan B, Wang Y.
europepmc   +1 more source