Results 81 to 90 of about 193,097 (307)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
High repetition rate femtosecond lightsource for CARS microscopy [PDF]
Conference Digest. 2000 Conference on Lasers and Electro-Optics Europe (Cat. No.00TH8505), 2000 The use of femtosecond pulsed excitation in microscopy permits the application of nonlinear optical techniques to microscopic studies of biological samples. Among the these techniques, the method of coherent anti-Stokes Raman scattering (CARS) is particularly promising for biological imaging since it allows spectrally selective probing for specific ...
Potma, Eric O. +3 more
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Stability of target irradiation for high-repetition rate direct-drive facilities
EPJ Web of Conferences, 2013 The illumination of a spherical target for Inertial Confinement Fusion is studied in the direct-drive approach. Three main sources of laser parameter fluctuation are taken into account, and a statistical analysis of the illumination configuration has ...
Schiavi Angelo +2 more
doaj +1 more source
Frequency‐swept high‐repetition rate optical source [PDF]
Microwave and Optical Technology Letters, 2020 AbstractWe propose and numerically validate an all‐optical scheme to generate optical pulse trains with varying temporal pulse‐to‐pulse delay and pulse duration. Our simulations confirm that applying a temporal sinusoidal phase modulation followed by a shaping of the spectral phase is efficient to maintain high‐quality Gaussian temporal profiles.
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Scaling of black silicon processing time by high repetition rate femtosecond lasers
MATEC Web of Conferences, 2013 Surface texturing of silicon substrates is performed by femtosecond laser irradiation at high repetition rates. Various fabrication parameters are optimized in order to achieve very high absorptance in the visible region from the micro-structured silicon
Nava Giorgio +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2023 Filamentation has been extensively explored and is well understood at repetition rates < 1 kHz due to the typical availability of multi-mJ laser systems at moderate average power.
Jean-Pierre Wolf (1505308) +7 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source