Results 41 to 50 of about 732,544 (302)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

偏遠地區國中小畢業生跨區升學、家長教育 期望、參與學校教育及學校選擇因素之探究 Correlations Between Interdistrict Enrollment, Parental Educational Expectation, Parental Involvement, and School Choice in Rural Areas

Journal of Research in Education Sciences, 2023
偏遠地區教育為我國近年教育政策發展之重點，但其中關乎偏遠地區國中小畢業生升學的家長學校選擇因素長期受到忽視，與此相關的家長教育期望、家長參與學校教育亦鮮有深入之研究。因此，本研究乃分析國中小畢業生跨區升學比率，以及家長教育期望、參與學校教育及學校選擇因素的現況與彼此關係，並探討學校層級、偏遠級別、家庭社經所造成的差 異，以及原區升學家長與跨區升學家長在學校選擇因素上的差異。本量化研究以臺灣偏遠地區國中小畢業生家長為研究對象，採用問卷調查法，最後回收有效問卷2,047份。依分析結果歸納結論如下：一 ...
簡瑋成 Wei-Cheng Chien, 謝傳崇 Chuan-Chung Hsieh   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Factors related to girls’ choice of physics for university entrance exams in Japan

Physical Review Physics Education Research, 2021
Women are underrepresented in physics. Because of the structure of the Japanese educational system, more women must choose physics as a subject for university entrance exams to increase the number of women studying advanced physics at university. In this
Yuko Ikkatai, Atsushi Inoue, Kei Kano, Azusa Minamizaki, Euan McKay, Hiromi M. Yokoyama   +5 more
doaj   +1 more source

The Lifetime Employment and Earnings Consequences of Dropping Out of High School in Philadelphia [PDF]

, 2009
What's the difference between a Philadelphia graduate and a high school dropout? About $580,000, according to this study which shows the difference in net fiscal contribution over a working lifetime (tax revenue generated vs.
Ishwar Khatiwada, Neeta P. Fogg, Paul E. Harrington   +2 more
core  

Estimating distributions of potential outcomes using local instrumental variables with an application to changes in college enrollment and wage inequality [PDF]

, 2009
This paper extends the method of local instrumental variables developed by Heckman and Vyt- lacil (1999, 2001, 2005) to the estimation of not only means, but also distributions of potential outcomes.
Carneiro, P., Lee, S.
core   +1 more source