Results 191 to 200 of about 28,827 (257)

A strong Pacific Walker Circulation during the Little Ice Age. [PDF]

Sci Adv
Hess AV, Wang S, Ummenhofer CC, Rosenthal Y, Oppo DW.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hotspots of Arctic and sub-Arctic marine sediment organic carbon are dominated by the Baltic, Barents and Chukchi Seas. [PDF]

Commun Earth Environ
Langley B, Burdett HL, Cameron K, Juul-Pedersen T, Rouillard A, Slaymark C, Kamenos NA.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Global Potential Refugia and Conservation Gaps for Threatened Marine Rays Under Future Climate Change. [PDF]

Animals (Basel)
Lu T, Li C, Liu W, Liu L, Li T, Pitriana P, Liu S.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ice-sheet dynamics drive glacial-interglacial shifts in North Atlantic seawater neodymium isotopes. [PDF]

Sci Adv
Xu A, Just K, Piotrowski AM, Stohl J, Frank N.   +4 more
europepmc   +1 more source

Human Rights as Justifications in Wildernesses: A Third World Approach to EU Law. [PDF]

Jus Cogens
Ganesh A.
europepmc   +1 more source

Regime transitions in Arctic surface momentum balance reveal persistent and predictable dynamical states. [PDF]

Nat Commun
Liu C, Liang X.
europepmc   +1 more source

Insolation-forced oceanic changes triggered the Eurasian Ice Sheet collapse and the Last Termination. [PDF]

Nat Commun
Wu D, Li S, Eiríksson J, Guðmundsdóttir ER, Rosenthal Y, Hu N, Fan D, Liu Y, Zhang X.   +8 more
europepmc   +1 more source