Results 91 to 100 of about 3,199,766 (245)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Sensitivity of the High Altitude Water Cherenkov Detector to Sources of Multi-TeV Gamma Rays [PDF]
, 2013 The High Altitude Water Cherenkov (HAWC) observatory is an array oflarge water Cherenkov detectors sensitive to gamma rays and hadronic cosmicrays in the energy band between 100 GeV and 100 TeV.
Alberto Carramiñana Alonso +7 more
core
, 2019 High-sensitivity and wide-linear-range thermoluminescence dosimeter (TLD) is of importance for detecting high-dose radiation in industry, medicine, and agriculture as well as materials and food processing.
Huaming Tang (6927854) +7 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Achieving a high sensitivity of sensors over a wide linear range is crucial for practical applications. Introducing various micronano topologies is the most effective approach to enhance sensor sensitivity.
Jie Chang (378968) +4 more
core +1 more source
, 2022 Magnetoelectric (ME) coupling is highly desirable for sensors and memory devices. Herein, the polarization (P) and magnetization (M) of the DyFeO3 single crystal were measured in pulsed magnetic fields, in which the ME behavior is modulated by multi ...
Zhuo Zeng (2414500) +11 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
High-Acoustic Sensitivity Radiopure Piezoelectric Materials for Dark Matter Detection
Piezoelectric materials are used to fabricate acoustic transducers for bubble chambers in search for particles of dark matter. It has been shown that bubbles initiated by nuclear recoils emit acoustic radiation distinguishable from the phase transitions ...
Aman Nanda (10723958) +11 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source