Results 101 to 110 of about 18,960,429 (284)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The clinical and diagnostic performance characteristics of the high sensitivity Abbott cardiac troponin I assay

, 2015
OBJECTIVES: The aim of this study is to determine the imprecision profile, 99th percentile and diagnostic efficiency of a new high sensitivity cardiac troponin I (cTnI) assay. METHODS: Total imprecision was assessed by following CLSI protocol EP15-A.14.
Gaze, D.C., Collinson, P., Goodacre, S.
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity [PDF]

, 2011
Background Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or ...
Pfeiffer, Andreas F. H., Arafat Ayman M, Leupelt Verena, Natalia Rudovich, Pfeiffer Andreas FH, Becker, Natalie, Verena Leupelt, Rudovich Natalia, Möhlig Matthias, Andreas FH Pfeiffer, Leupelt, Verena, Carl Alpert, Blaut Michael, Martin O Weickert, Arafat, Ayman M., Becker Natalie, Michael Blaut, Weickert Martin O, Weickert, Martin O., Möhlig, Matthias, Alpert, Carl, Rudovich, Natalia, Matthias Möhlig, Blaut, Michael, Natalie Becker, Alpert Carl, Ayman M Arafat   +26 more
core   +1 more source

Piezo-VFETs: Vacuum Field Emission Transistors Controlled by Piezoelectric MEMS Sensors as an Artificial Mechanoreceptor with High Sensitivity and Low Power Consumption

Sensors
As one of the most promising electronic devices in the post-Moore era, nanoscale vacuum field emission transistors (VFETs) have garnered significant attention due to their unique electron transport mechanism featuring ballistic transport within vacuum ...
Chang Ge, Yuezhong Chen, Daolong Yu, Zhixia Liu, Ji Xu   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

High Sensitive Polarography

Review of Polarography, 1960
Ordinary polarography was introduced to our company in 1949 for the analysis of lead and cadmium in zinc, copper and zinc in ore and has been used for the analysis of metallurgical products and others.It has recently been ascertained too by our experiments that square wave polarographic method is superior to the ordinary polarographic method for the ...
openaire   +2 more sources

Development of a NIR Iridium(III) Complex-Based Probe for the Selective Detection of Iron(II) Ions

Biosensors
As a commonly used metal ion, iron(II) (Fe2+) ions pose a potential threat to ecosystems and human health. Therefore, it is particularly important to develop analytical techniques for the rapid and accurate detection of Fe2+ ions.
Wanyi Wang, Zixi Zhang, Jingqi Liu, Lingtan Kong, Wanhe Wang, Chung-Hang Leung, Jing Wang   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source