Results 121 to 130 of about 164,121 (308)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

New single-switch buck–boost converter with continuous input/output currents and a wide conversion range

Heliyon
The main aim of this paper is to introduce a new high step-up/down buck-boost converter with a minimum number of switches which provides the benefit of having the continuity of the input/output current.
Mohammad Lotfi-nejad, Hossein Hajisadeghian, Amir Abbas Aghajani, Ali A. Motie Birjandi, Ehsan Adib   +4 more
doaj   +1 more source

High-frequency high-voltage high-power DC-to-DC converters [PDF]

The current and voltage waveshapes associated with the power transitor and the power diode in an example current-or-voltage step-up (buck-boost) converter were analyzed to highlight the problems and possible tradeoffs involved in the design of high ...
Owen, H. A., Jr., Wilson, P. M., Wilson, T. G.   +2 more
core   +1 more source

Switched Capacitor Voltage Converter [PDF]

, 2019
This project supports IoT development by reducing the power con- sumption and physical footprint of voltage converters. Our switched- capacitor IC design steps down an input of 1:0 - 1:4 V to 0:6 V for a decade of load current from 5 ...
Hsia, Anne, Kidd, Bradford
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A high step‐up high step‐down coupled inductor based bidirectional DC–DC converter with low voltage stress on switches

IET Power Electronics
This paper proposes, a novel soft‐switching bidirectional direct current to direct current (DC–DC) converter based on switched‐capacitor and coupled‐inductor.
Pouya Abolhassani, Mohammad Maalandish, Ali Nadermohammadi, Mohammad Bagher Bannae Sharifian, Mohammad Reza Feyzi, Seyed Hossein Hosseini   +5 more
doaj   +1 more source

Ultra-High Gain Quadratic DC-DC Topology Using Two-Winding Coupled Inductors With Voltage Multiplier Cells

IEEE Open Journal of Power Electronics
High-gain DC-DC converters have become very important devices in the operation of renewable energy methods such as wind and solar power to provide the required voltage and current levels.
Sohrab Abbasian, Mohammad Farsijani, Homayon Soltani Gohari, Tomi Roinila   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Digital servo control of random sound test excitation [PDF]

, 1974
A digital servocontrol system for random noise excitation of a test object in a reverberant acoustic chamber employs a plurality of sensors spaced in the sound field to produce signals in separate channels which are decorrelated and averaged. The average
Nakich, R. B.
core   +1 more source

The Alternate Arm Converter: A New Hybrid Multilevel Converter With DC-Fault Blocking Capability

, 2013
This paper explains the working principles, supported by simulation results, of a new converter topology intended for HVDC applications, called the alternate arm converter (AAC).
Critchley, R, Crookes, W, Green, TC, Hassan, F, Merlin, MMC, Mitcheson, PD, Trainer, DR   +6 more
core   +1 more source