Results 31 to 40 of about 78,780 (311)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Performance assessment of a novel auto-cascade heat pump using low-GWP refrigerant for obtaining high-temperature water [PDF]

International Journal of Fluid Engineering
With the aim of developing a high-temperature heat pump with a large temperature lift, a novel auto-cascade heat pump using low global warming potential (GWP) refrigerant is proposed. Owing to the large exergy destruction between the refrigerant and heat
Gang Yan, Yuqing Yang, Yinlong Li
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Domestic Hot Water Production with Ground Source Heat Pump in Apartment Buildings

Energies, 2015
Producing domestic hot water (DHW) with a ground source heat pump (GSHP) is challenging due to the high temperature (HT) of DHW. There are many studies proving the better performance of cascade heat pumps compared to single-stage heat pumps when the ...
Jukka Yrjölä, Eetu Laaksonen
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Feasibility Analysis of Industrial High-Temperature Heat Pumps in Greece

Applied Sciences
The high-temperature heat pump is a favorable technology for aiding the decarbonization of the industrial sector through its electrification. It can produce useful heat up to the range of 100 °C to 200 °C; however, additional steps are needed to develop ...
Evangelos Bellos, Dimitra Gonidaki, Antonios Nazos, John K. Kaldellis   +3 more
doaj   +1 more source

Research on the characteristics of dual-temperature heat pump based on refrigerant leakage [PDF]

Journal of Hebei University of Science and Technology
In order to meet the demand for dual-temperature heating in production and life, a dual-temperature heat pump system based on refrigerant leakage was proposed. By establishing and verifying the mathematical model and system model of the scroll compressor
Diankang WU, Fenglei LI, Xiutian WANG, Baocun DU   +3 more
doaj   +1 more source

A Hybrid Compression-Absorption High Temperature Heat Pump Cycles for Industrial Waste Heat Recovery

Shanghai Jiaotong Daxue xuebao, 2021
Aimed at the problem that the conventional absorption heat pumps and compression heat pumps cannot take into account the temperature rise and efficiency, this paper proposes the use of a thermally-coupled hybrid compression-absorption heat pump to ...
AN Meiyan, ZHAO Xinrui, XU Zhenyuan, WANG Ruzhu
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source