Results 81 to 90 of about 4,585,274 (405)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The high temperature oxidation of metals [PDF]

Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1926
Abstract The oxidation of metals at high temperatures has been investigated with some thoroughness by Pilling and Bedworth. They found that the metals could be divided into two great classes according to the nature of the oxide produced.
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Silicon-technology based microreactors for high-temperature heterogeneous partial oxidation reactions [PDF]

, 2004
In this thesis the results of a study into the feasibility of silicon-technology based microreactors for fast oxidation reactions have been discussed.
Tiggelaar, Roald Michel
core   +7 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High-Temperature Cyclic Oxidation Data, Volume 1 [PDF]

This first in a series of cyclic oxidation handbooks contains specific-weight-change-versus-time data and X-ray diffraction results derived from high-temperature cyclic tests on high-temperature, high-strength nickel-base gamma/gamma' and cobalt-base ...
Barrett, C. A., Garlick, R. G., Lowell, C. E.   +2 more
core   +1 more source

Insights into the function of silver as an oxidation catalyst by ab initio, atomistic thermodynamics [PDF]

, 2003
To help understand the high activity of silver as an oxidation catalyst, e.g., for the oxidation of ethylene to epoxide and the dehydrogenation of methanol to formaldehyde, the interaction and stability of oxygen species at the Ag(111) surface has been ...
A. Deb, A. Kokalj, A. Kokalj, A. Michaelides, A. Nagy, A. Nagy, A. Nagy, B. Hammer, B. Pettinger, B. Pettinger, B.L.M. Hendriksen, C. Rehren, C. Stampfl, C. Stampfl, C. Stampfl, C. Stampfl, C. Stampfl, C.I. Carlisle, C.I. Carlisle, C.M. Weinert, C.T. Campbell, C.T. Campbell, Catherine Stampfl, D. Herein, E. Kaxiras, G. Cipriani, G. Rovida, G.-X. Qian, G.A. Somorjai, G.C. Bond, G.I.N. Waterhouse, G.I.N. Waterhouse, H. Schubert, H.J. Freund, J. Chevrier, J. Neugebauer, J.A. White, J.K. Nørskov, J.P. Perdew, K. Reuter, K. Reuter, K. Reuter, K.B. Rider, K.F. Peters, K.P. Jayadevan, L. Savio, L.H. Tjeng, M. Bockstedte, M. Fuchs, M. Gajdos̆, M. Rocca, M. Rocca, M. Scheffler, M. Staedele, M. Taniguchi, M. Todorova, M.-L. Bocquet, M.-L. Bocquet, M.K. Bhan, M.T. Czyzyk, Matthias Scheffler, N. Troullier, Q. Sun, R. Asahi, R. Schaub, R.A. van Santen, R.A. van Santen, R.B. Grant, R.B. Grant, S. Bare, S. Dahl, S. Linic, S. Linic, S. Linic, S.L. Cunningham, T. Zambelli, Th. Schedel-Niedrig, V.I. Avdeev, V.I. Bukhtiyarov, V.I. Bukhtiyarov, V.I. Bukhtiyarov, W.X. Li, W.X. Li, W.X. Li, Wei-Xue Li, X. Bao, X.G. Wang, Y. Uchida   +87 more
core   +2 more sources

Kinetic modeling of high-temperature oxidation of pure Mg

, 2020
A variety of experimental tracer diffusivities of Mg and O in magnesium oxide available in the literature were first assessed. Atomic mobilities including bulk and short-circuit diffusion of Mg and O were then obtained by means of the CALPHAD ...
Sa Ma, Fangzhou Xing, N. Ta, Lijun Zhang
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source