Results 221 to 230 of about 15,635,515 (278)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Statistical characterization of non-condensable gas distribution morphology in high-temperature sodium heat pipes through discretized thermal resistance network

open access: gold
Haoran Wang   +9 more
openalex   +1 more source

Superstrings at High Temperature

Physical Review Letters, 1985
The behavior of ten-dimensional superstrings at high temperatures is studied by use of the microcanonical ensemble. We focus on closed superstring theories. The massive string excitations alone have negative specific heat. Such a system can reach equilibrium with the zero modes of the string if the energy carried by zero modes is less than a given ...
, Bowick, , Wijewardhana
openaire   +2 more sources

Life at High Temperatures

Science, 1985
Water environments with temperatures up to and above boiling are commonly found in association with geothermal activity. At temperatures above 60°C, only bacteria are found. Bacteria with temperature optima over the range 65° to 105°C have been obtained in pure culture and are the object of many research projects.
openaire   +2 more sources

Fermions at high temperature

Physical Review D, 1990
We calculate the self-energy of massless fermions interacting with massless bosons at high temperature by summing the set of ring diagrams. This leads to an effective one-loop equation. We further approximate the boson self-energy by a temperature-dependent mass squared which is of order ({ital gT}){sup 2}. At low momenta, {ital p}{lt}{ital g}{sup 2}T,
Gatoff, G., Kapusta, J.
openaire   +2 more sources

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