Results 71 to 80 of about 14,831,642 (287)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

A Review of Imaging Techniques for Plant Phenotyping

open access: yesSensors, 2014
Given the rapid development of plant genomic technologies, a lack of access to plant phenotyping capabilities limits our ability to dissect the genetics of quantitative traits. Effective, high-throughput phenotyping platforms have recently been developed
Lei Li, Qin Zhang, Danfeng Huang
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

High-throughput phenotyping using digital and hyperspectral imaging-derived biomarkers for genotypic nitrogen response

open access: yes, 2020
A correction has been published: Journal of Experimental Botany, Volume 72, Issue 13, 22 June 2021, Page 5093, https://doi.org/10.1093/jxb/erab126Abstract:The development of crop varieties with higher nitrogen use efficiency is crucial for sustainable ...
German Spangenberg (9477560)   +7 more
core   +2 more sources

An automatable, field camera track system for phenotyping crop lodging and crop movement

open access: yesHardwareX, 2018
High throughput phenotyping systems enable rapid data collection for plant breeders. Some plant traits such as lodging, or the breaking and falling over of plant stems under wind stress, are complex and not easily measured through existing high ...
Alexander Q. Susko   +4 more
doaj   +1 more source

Optimizing pollencounter for high throughput phenotyping of pollen quality in tomatoes

open access: yesMethodsX, 2020
The macro “PollenCounter” in ImageJ was initially developed to assess pollen viability in grapevine. We set out to see if PollenCounter could be used to assess pollen number and viability in tomatoes.
Mathieu Anatole Tele Ayenan   +5 more
doaj   +1 more source

High throughput phenotyping of cross-sectional morphology to assess stalk lodging resistance

open access: yesPlant Methods, 2022
Background Stalk lodging (mechanical failure of plant stems during windstorms) leads to global yield losses in cereal crops estimated to range from 5% to 25% annually.
Yusuf A. Oduntan   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

TERMINOLOGICAL MAPPING FOR HIGH THROUGHPUT COMPARATIVE BIOLOGY OF PHENOTYPES [PDF]

open access: yesBiocomputing 2004, 2003
Comparative biological studies have led to remarkable biomedical discoveries. While genomic science and technologies are advancing rapidly, our ability to precisely specify a phenotype and compare it to related phenotypes of other organisms remains challenging.
Yves A. Lussier, Jianrong Li
openaire   +3 more sources

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