Results 111 to 120 of about 9,407,231 (337)

Towards Highly Accurate and Stable Face Alignment for High-Resolution Videos

, 2018
In recent years, heatmap regression based models have shown their effectiveness in face alignment and pose estimation. However, Conventional Heatmap Regression (CHR) is not accurate nor stable when dealing with high-resolution facial videos, since it ...
Chen, Yu, Duan, Lei, Huang, Feiyue, Li, Jilin, Liang, Yicong, Liu, Xiaoming, Tai, Ying, Wang, Chengjie   +7 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The High Time Resolution Universe pulsar survey - X. Discovery of four millisecond pulsars and updated timing solutions of a further 12 [PDF]

, 2014
We report on the discovery of four millisecond pulsars (MSPs) in the High Time Resolution Universe (HTRU) pulsar survey being conducted at the Parkes 64-m radio telescope. All four MSPs are in binary systems and are likely to have white dwarf companions.
C. Ng, M. Bailes, S. Bates, N. Bhat, N. Bhat, M. Burgay, S. Burke-Spolaor, D. Champion, P. Coster, P. Coster, S. Johnston, Michael J. Keith, M. Kramer, M. Kramer, L. Levin, E. Petroff, E. Petroff, A. Possenti, B. Stappers, W. Straten, D. Thornton, D. Thornton, C. Tiburzi, C. Bassa, P. Freire, L. Guillemot, L. Guillemot, A. Lyne, T. Tauris, T. Tauris, Ryan M. Shannon, N. Wex   +31 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A demonstration of ultra-high time resolution with a pulse-dilation photo-multiplier

, 2016
A novel microchannel plate (MCP) intensified high-speed photo-multiplier tube making use of pulse-dilation[1] has been tested. A ramped photo-cathode voltage followed by a relatively long drift region results in a transit time which is dependent on the ...
J. Hares, A. Dymoke-Bradshaw, T. Hilsabeck, J. Kilkenny, D. Morris, C. Horsfield, S. Gales, J. Milnes, H. Herrmann, C. Mcfee   +9 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Modeling the Epps effect of cross correlations in asset prices

, 2007
We review the decomposition method of stock return cross-correlations, presented previously for studying the dependence of the correlation coefficient on the resolution of data (Epps effect).
Kertesz, Janos, Toth, Balint, Toth, Bence   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source