Results 121 to 130 of about 1,871,500 (313)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Decadal to millennial time scale climate variability in the Central Mediterranean during the Holocene: a reconstruction based on geochemical proxies from high resolution sedimentary records

, 2014
To assess potential anthropogenic contributions to future climate change it is necessary to understand natural climate variability. This can be achieved by studying climate variability during the Holocene, when similar basic climate boundary conditions ...
Goudeau, M.S., Marine geochemistry, NWO-ALW Open: Multidisciplinary study Of Continental/ocean Climate dynamics using High-resolution records from the eastern MediterraneAn (MOCCHA)   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

High resolution modelling for performance assessment of future dwellings

, 2014
In future low-energy buildings, electrical power and hot water use will feature prominently in the overall energy demand. Unlike space heating, these demand constituents are intermittent and vary rapidly over a few seconds.
Kelly, Nicolas, Samuel, Aizaz, Hand, Jon
core  

Investigation and development of DSP algorithms/hardware for real time power spectral density estimation [PDF]

, 1993
This research is concerned with the Power Spectrum Density Estimation with em- phasIze on the bigh-resolution algorithms and their real-time implementations. Tl-ie classical PSD estimation methods are fast and robust.
Sung-Yuan, Ko
core  

Time-Domain Off-Grid Sparse Bayesian Learning for High-Resolution Time-Delay Estimation

IEEE Access
When estimating the acoustic channel impulse response (CIR) at low frequencies, matched filter (MF)-based methods suffer from limited resolution due to the narrow source bandwidth.
Haesang Yang, Youngmin Choo
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

On-chip timing measurement architecture with femtosecond resolution

, 2006
A new timing measurement architecture based on the time-to-digital conversion technique is presented. The architecture occupies a small silicon area (200x185µm) in a 0.12µm CMOS Process and can achieve tens of femtoseconds timing resolution, which is the
Al-Hashimi, Bashir, Collins, Matthew, Wilson, Peter   +2 more
core  

High Time Resolution Analysis of Voltage-Dependent and Voltage-Independent Calcium Sparks in Frog Skeletal Muscle Fibers. [PDF]

Front Physiol, 2020
Cserne Szappanos H, Vincze J, Bodnár D, Dienes B, Schneider MF, Csernoch L, Szentesi P.   +6 more
europepmc   +1 more source