Results 141 to 150 of about 1,871,500 (313)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Supplemental Material, Appendix_A_overall_search_strategy - Time to go wild: How to conceptualize and measure process dynamics in real teams with high-resolution

, 2019
Supplemental Material, Appendix_A_overall_search_strategy for Time to go wild: How to conceptualize and measure process dynamics in real teams with high-resolution by Florian Klonek, Fabiola Heike Gerpott, Nale Lehmann-Willenbrock and Sharon K. Parker in
Florian Klonek (7915883), Sharon K. Parker (6424403), Fabiola Heike Gerpott (7915886), Nale Lehmann-Willenbrock (7915889)   +3 more
core   +1 more source

High resolution temperature forecasting using functional time series decomposition and advanced predictive models

Scientific Reports
The air temperature (AT) is a significant factor in the environmental processes, human health, agriculture, and energy systems, so correct forecasting is very important.
Huda M. Alshanbari, Musaad S. Aldhabani, Naveed Iqbal, Abdulkafi Mohammed Saeed, Noorullah Noori   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

, 2015
Purpose: Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the retinal pigment epithelium (RPE). During SRT, the detection of an immediate tissue reaction is challenging as tissue effects remain limited to ...
Sznitman, Raphael, Berger, Lieselotte Erika, Framme, Carsten Karl Josef, Brinkmann, Ralf, Kowal, Horst Jens, Steiner, Patrick, Zinkernagel, Martin, Povazay, Boris, Meier, Christoph, Ebneter, Andreas, Wolf, Sebastian   +10 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Supplemental Material, Appendix_B_List_of_Studies - Time to go wild: How to conceptualize and measure process dynamics in real teams with high-resolution

, 2019
Supplemental Material, Appendix_B_List_of_Studies for Time to go wild: How to conceptualize and measure process dynamics in real teams with high-resolution by Florian Klonek, Fabiola Heike Gerpott, Nale Lehmann-Willenbrock and Sharon K.
Florian Klonek (7915883), Sharon K. Parker (6424403), Fabiola Heike Gerpott (7915886), Nale Lehmann-Willenbrock (7915889)   +3 more
core   +1 more source

Polarization control with an X-ray phase retarder for high-time-resolution pump-probe experiments at SACLA. [PDF]

J Synchrotron Radiat, 2019
Kubota Y, Suzuki M, Katayama T, Yamamoto K, Tono K, Inubushi Y, Seki T, Takanashi K, Wadati H, Yabashi M.   +9 more
europepmc   +1 more source