Results 91 to 100 of about 16,307,830 (290)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2009 application/pdf; "February 2, 2009."; Testimony before the Kansas Legislature, House Utilities Committee, presented by David Springe, Consumer Counsel, Citizens' Utility Ratepayer Board.Testimony regarding House Bill 2116.
Springe, David.
core +1 more source
HIGH-TEMPERATURE DECONTAMINATION AND UTILIZATION OF PHOSPHOGYPSUM
JOURNAL OF ENVIRONMENTAL ENGINEERING AND LANDSCAPE MANAGEMENT, 2004 Waste piles of phosphogypsum formed from deposits of phosphoric acid production by‐product loom near the city of Kedainiai in the center of Lithuania. Every year about 250 thousand tons of this by‐product were gathered when the plant was in full operation.
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2008 application/pdf; "February 6, 2008."; Includes a copy of testimony on House Bill 2682 presented before the Kansas Legislature, House Utilities Committee, by David Springe, Consumer Counsel, Citizens' Utility Ratepayer Board on January 31, 2008.;
Springe, David.
core +1 more source
IEEE Access, 2018 High average-utility itemsets mining (HAUIM) is an emerging topic in data mining. Compared to traditional high utility itemset mining, HAUIM more fairly measures the utility of itemsets by considering their lengths (number of items).
Jerry Chun-Wei Lin +2 more
doaj +1 more source
Scalable Sampling for High Utility Patterns
2024 IEEE International Conference on Big Data (BigData)Discovering valuable insights from data through meaningful associations is a crucial task. However, it becomes challenging when trying to identify representative patterns in quantitative databases, especially with large datasets, as enumeration-based strategies struggle due to the vast search space involved.
Lamine Diop, Marc Plantevit
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
, 2009 application/pdf; "January 29, 2009."; Includes the exact same testimony which was presented to the House Utilities Committee by David Springe, Consumer Counsel, also on January 29, 2009, concerning House Bill 2051.; Testimony before the Kansas ...
Springe, David.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source