Results 81 to 90 of about 938,194 (261)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
IEEE Access, 2018 High average-utility itemsets mining (HAUIM) is an emerging topic in data mining. Compared to traditional high utility itemset mining, HAUIM more fairly measures the utility of itemsets by considering their lengths (number of items).
Jerry Chun-Wei Lin +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Scalable Sampling for High Utility Patterns
2024 IEEE International Conference on Big Data (BigData)Discovering valuable insights from data through meaningful associations is a crucial task. However, it becomes challenging when trying to identify representative patterns in quantitative databases, especially with large datasets, as enumeration-based strategies struggle due to the vast search space involved.
Lamine Diop, Marc Plantevit
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
An Efficient Approach for Mining High Average-Utility Itemsets in Incremental Database
Engineering ProceedingsTraditional high-utility itemset (HUI) mining methods tend to overestimate utility for long itemsets, leading to biased results. High average-utility itemset (HAUI) mining addresses this problem by normalizing utility with itemset length.
Ye-In Chang +2 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Student Perspectives With a High-Utilizing Patient
Journal of Patient Experience, 2016 It could have been any time, on any day, in any doctor’s waiting room, but today was different. Today, I was sitting with Mrs Murphy and she was scared. She insisted we call her Paula. She stopped smoking a month ago, but she was nervous and the undeniable smell of Parliaments wafted from her clothes while we waited. The analog clock on the wall ticked
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source