Results 191 to 200 of about 1,842,676 (314)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Multiscale Engineering of PEO Electrolytes for High-Voltage and Ultrastable Solid-State Lithium Batteries With Exceptional Room-Temperature Performance. [PDF]

Angew Chem Int Ed Engl
Liu X, Zhang B, Zhang C, Zhou X, Liu X, Liu T, Hou S, Zheng Q, Wang L, Kong L, Zhang S.   +10 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Decoding High-voltage LiCoO₂: From Degradation to Stabilization Toward Durable Li-ion Batteries. [PDF]

Adv Mater
Lin Z, Ying Y, Li H, Ren Y, Liu T, Hou P, Huang H.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

High Voltage and Train-Surfing Injuries: A 30-Year Retrospective Analysis of High-Voltage Trauma and Its Impact on Cardiac Biomarkers. [PDF]

J Clin Med
Koenig V, Monai M, Christ A, Windpassinger M, Ihra GC, Fochtmann-Frana A, Joestl J.   +6 more
europepmc   +1 more source

High voltage activated Ca2+ channel [PDF]

, 1993
A Cavalié, A Hui, A Mikami, A Röhrkasten, A Welling, A Welling, AE Lacerda, AM Brown, C Kleuss, C Mundina-Weilenmann, D Singer, E Bosse, E Bosse, E Perez-Reyes, E Perez-Reyes, E Perez-Reyes, E Rios, EI Rotman, F Hofmann, G Varadi, H Nakayama, HL Kim, HR Guy, HS Kim, IM Mintz, J Garcia, J Striessnig, J Striessnig, K Itagaki, K Nunoki, KS Jongh De, KS Jongh De, KS Jongh De, L Hymel, M Bertolino, M Biel, M Biel, M Kameyama, M Pragnell, ME Williams, ME Williams, P Lory, P Ruth, R Hullin, R Staudinger, RI Norman, RJ Diebold, RJ Miller, RS Kass, S Hamilton, S Regulla, S Seino, SB Ellis, SD Jay, SD Jay, SJ Dubel, T Schneider, T Tanabe, T Tanabe, T Tanabe, T Tanabe, TP Snutch, TP Snutch, TVB Starr, U Klöckner, V Flockerzi, W Trautwein, WJ Koch, X Wei, Y Lai, Y Mori   +70 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A step-up DC-DC converter with high voltage gain and soft switched capability and minimum phase characteristic. [PDF]

Sci Rep
Salehi SM, Varjani AY.
europepmc   +1 more source