Results 101 to 110 of about 1,739,474 (329)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Should We Fear Derivatives? [PDF]

This paper discusses the extent to which derivatives pose threats to firms and to the economy. After reviewing the derivatives markets and putting in perspective the various measures of the size of these markets, the paper shows who uses derivatives and ...
Rene M. Stulz
core  

Finite temperature Casimir effect of a Lorentz-violating scalar with higher order derivatives

European Physical Journal C: Particles and Fields
In this work I study the finite temperature Casimir effect caused by a complex and massive scalar field that breaks Lorentz invariance in a CPT-even, aether-like manner.
Andrea Erdas
doaj   +1 more source

Analyzing Higher-Order Curvature of Four-Bar Linkages with Derivatives of Screws

Machines
Curvature theory, a fundamental subject in kinematics, is typically addressed through the concepts of instantaneous invariants and canonical coordinates, which are pivotal for the generation of mechanical paths. This paper delves into this subject with a
Liheng Wu, Jianguo Cai, Jian S. Dai
doaj   +1 more source

Nontrivial Solutions for a Higher Order Nonlinear Fractional Boundary Value Problem Involving Riemann-Liouville Fractional Derivatives

Journal of Function Spaces, 2019
In this paper using topological degree we study the existence of nontrivial solutions for a higher order nonlinear fractional boundary value problem involving Riemann-Liouville fractional derivatives.
Keyu Zhang, Donal O’Regan, Jiafa Xu, Zhengqing Fu   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Convergence Analysis of Weighted-Newton Methods of Optimal Eighth Order in Banach Spaces

Mathematics, 2019
We generalize a family of optimal eighth order weighted-Newton methods to Banach spaces and study their local convergence. In a previous study, the Taylor expansion of higher order derivatives is employed which may not exist or may be very expensive to ...
Janak Raj Sharma, Ioannis K. Argyros, Sunil Kumar   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Implicit two-point block method with third and fourth derivatives for solving general second order ODEs

, 2019
In this paper we present an implicit two-point block method for solving directly the general second order ordinary differential equations (ODEs). The method incorporates the first and second derivatives of f(x; y; y 0), which are the third and fourth ...
Ismail, Fudziah, Ibrahim, Zarina Bibi, Allogmany, Reem Ayed   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source