Results 131 to 140 of about 4,518,702 (324)

Exploring number of response categories in factor analysis: Implications for sample size

open access: yesInternational Journal of Assessment Tools in Education
Factor analysis is a statistical method to explore the relationships among observed variables and identify latent structures. It is crucial in scale development and validity analysis.
Fatih Orçan
doaj   +1 more source

Operads in Higher-Dimensional Category Theory

open access: yesTheory and Applications of Categories, 2004
The purpose of this dissertation is to set up a theory of generalized operads and multicategories, and to use it as a language in which to propose a definition of weak n-category. Included is a full explanation of why the proposed definition of n-category is a reasonable one, and of what happens when n=2.
openaire   +4 more sources

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Ethnic Differences in Weight Category Transition and Body Mass Index Trajectories from Adolescence to Young Adulthood in Israel

open access: yesChildren
Objective: To assess ethnic differences in the transition of weight categories and in BMI trajectories from adolescence to young adulthood between Jewish and Arab populations.
Yulia Treister-Goltzman   +2 more
doaj   +1 more source

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