Results 131 to 140 of about 20,149,656 (379)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Tennessee Higher Education Fact Book 2011-2012 [PDF]

open access: yes, 2013
https://digitalcommons.memphis.edu/govpubs-tn-higher-education-commission-higher-education-fact-book/1011/thumbnail ...
Tennessee. Higher Education Commission.
core   +1 more source

Globalization and Higher Education [PDF]

open access: yesHigher Education in Europe, 2001
The question of the role of higher education in society and culture today is linked, in this article, with two parallel processes: the questioning of the nation-state in the global age and the gradual decomposition of the welfare state in the majority of the OECD countries.
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Viktorija Stokaitė

open access: yesSocial Technologies, 2012
The Chairman of the European Commission J.M Barroso, as the main “Europe 2020” strategic target for the upcoming ten years, indicates the creation of an innovative, stable and integrated economy.
Promoting Entrepreneurship in Higher Education: Analysis of European Union Documents and Lithuanian Case Study
doaj  

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