Results 51 to 60 of about 7,501,853 (298)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cogent Engineering, 2019 Drilling is a salient machining process employed in assembling the components and structures made from polymer composites. Influence of various drilling process parameters on the drilling process has been identified and controlled to maintain the ...
B. R. N. Murthy +6 more
doaj +1 more source
Investing in Higher Education [PDF]
, 2004 Kirby (Noland) Dyess ‘68 learned early on she could do whatever she put her mind ...
Davis, Laura
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Optimized trapezoidal-shaped hip implant for total hip arthroplasty using finite element analysis
Cogent Engineering, 2020 Hip implants consist of a stem, femoral head, acetabular cup, and backing cup. There is a wide variety of sizes and lengths. Their adaptability is limited because of the inter-anatomical variations.
Chethan K N +3 more
doaj +1 more source
SOA services in higher education [PDF]
, 2008 Service Oriented Architecture (SOA) is a recent architectural framework for distributed software system development in which software components are packaged as Services.
Joy, Mike +1 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
SAGE Open, 2019 Cancer is the most dreaded and chronic disease with its treatment lasting almost lifelong with an uncertainty of cure. This not only adversely affects the quality of life among patients but also poses a psychosocial burden among family members ...
Bhaskaran Unnikrishnan +7 more
doaj +1 more source
Journal of Chest Surgery, 2021 Background: Refractory empyemas with collapsed lung and persistent bronchopleural fistulas pose significant problems to thoracic surgeons and impose a substantial burden in terms of morbidity and mortality.
Rajkamal Vishnu +3 more
doaj +1 more source