Results 71 to 80 of about 2,173,028 (256)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Evaluation of mean glandular dose in relation to breast density in digital mammography
The Egyptian Journal of Radiology and Nuclear MedicineBackground Mammography is considered an ideal tool for breast cancer screening due to its proven effectiveness, which has led to its widespread use as the primary imaging modality for early detection.
Fatemeh Amiri +7 more
doaj +1 more source
Higher Education—Educating for Higher Order Skills
Creative Education, 2013 Preparing college students for a knowledge-based economy is a challenge that requires curriculum design that puts more emphasis on learning skills than on content to be taught. Cognitive skills should be practiced in a context of some content, but the choice of content, the choice of the learning environment, and the choice of the assessment procedures
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Discover NanoThis paper describes the potential of carbon dot nanocomposites (CDs) synthesized from waste materials by top-down and bottom-up state-of-the-art approaches.
S. Varadharajan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Paddy fields detection on Sentinel-2 satellite images using EfficientDet model
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie ŚrodowiskaAgricultural monitoring plays an important role in ensuring food security and sustainable farming practices. This project focuses on the task of paddy field detection on the satellite images collected from the agricultural lands of Andhra Pradesh. Using
Suvarna Vani Koneru +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source