Results 161 to 170 of about 2,323,053 (317)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Higher education institutions can accelerate societal climate action. [PDF]

Bioscience
Kopp RE, Lippel PH, Teutonico R, Crowl T, Dorhout PK, Han S, Harvey E, Krosby M, Newman J, Thomas RM, Tolstoy M.   +10 more
europepmc   +1 more source

Welsh in higher education institutions, 2011/12 [PDF]

, 2013
Evans, Siobhan
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Physical Fitness and Physical Activity in Young Adults: A Comparative Study Between Two Higher Education Institutions. [PDF]

J Funct Morphol Kinesiol
Sampaio T, Oliveira JP, Magalhães PM, Bragada JA, Bartolomeu RF, Vasques C, Morais JE.   +6 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Access and utilization of e-learning on tropical medicine at higher education institutions in Indonesia: A mixed-methods study. [PDF]

PLoS One
Pamungkasari EP, Maftuhah A, Dierickx S, Hermasari BK, Widyaningsih V, Mashuri YA, Laras AA, Harjanti AS, Al Biruni NS, Maulani UN, Alcedo S, Murhandarwati EH, Probandari A, Zolfo M.   +13 more
europepmc   +1 more source

Emerging ESG reporting of higher education institutions in China. [PDF]

Heliyon, 2023
Mo F, Wang DD.
europepmc   +1 more source

Students in higher education institutions : Wales, 2010/11 [PDF]

, 2012
Irshad, Amira
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source