Results 131 to 140 of about 15,411,558 (330)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Higher Time-Derivative Theories from Space–Time Interchanged Integrable Field Theories

Universe
We compare a relativistic and a nonrelativistic version of Ostrogradsky’s method for higher-time derivative theories extended to scalar field theories and consider as an alternative a multi-field variant.
Andreas Fring, Takano Taira, Bethan Turner   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On Non-Point Invertible Transformations of Difference and Differential-Difference Equations

Symmetry, Integrability and Geometry: Methods and Applications, 2010
Non-point invertible transformations are completely described for difference equations on the quad-graph and for their differential-difference analogues. As an illustration, these transformations are used to construct new examples of integrable equations
Sergey Ya. Startsev
doaj   +1 more source

Random Matrix Theory and higher genus integrability: the quantum chiral Potts model

, 2002
We perform a Random Matrix Theory (RMT) analysis of the quantum four-state chiral Potts chain for different sizes of the chain up to size L=8. Our analysis gives clear evidence of a Gaussian Orthogonal Ensemble statistics, suggesting the existence of a ...
, Albertini G, Anglès d'Auriac J-C, Bashilov Y A, Baxter R, Bohigas O, Bruus H, Bruus H, C M Viallet, Chevalley C, Dasmahapatra S, Dieudonné J-A, Dupuis N, Dyson F J, Dyson F J, Dyson F J, Fan C, Forrester P J, Forrester P J, Forrester P J, Gaudin M, Georges A, Gutzwiller M C, J-Ch Angl$egrave$s d$apos$Auriac, J-M Maillard, Jaekel M T, Jaekel M T, Kasteleyn P W, Lapack Library, Lieb E H, Maillard J-M, Maillard J-M, Mehta M L, Meyer H, Meyer H, Poilblanc D, Robnik M, Sutherland B, Tracy C A, von Gehlen G, von Gehlen G, Weyl H, Wigner E P, Wigner E P, Wigner E P, Wigner E P   +45 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

On the nonintegrability of equations for long- and short-wave interactions

, 2018
We examine the integrability of two models used for the interaction of long and short waves in dispersive media. One is more classical but arguably cannot be derived from the underlying water wave equations, while the other one was recently derived.
Deconinck, Bernard, Upsal, Jeremy
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Integrating Lifelong Learning into Higher Education

ACROSS Journal of Interdisciplinary Cross-border Studies
Current European policies and trends in education demonstrate the importance of implementing the concept of lifelong learning and its impact on economic development, society and every individual. The revitalization of lifelong learning requires rethinking how this concept can lead to overcoming existing constraints and dysfunctions and become viable ...
Şavga, L.A., Liviţchi, O.T.
openaire   +4 more sources