Results 141 to 150 of about 15,411,558 (330)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Quantum anomalies in A r (1) Toda theories with defects
Journal of High Energy Physics, 2019 We study quantum integrability of affine Toda theories with a line of defect. In particular, we focus on the problem of constructing quantum higher-spin conserved currents in models defined by two A r (1) Toda theories separated by a non-trivial type-I ...
Silvia Penati, Davide Polvara
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Gauge Integral Theory in HOL4
Journal of Applied Mathematics, 2013 The integral is one of the most important foundations for modeling dynamical systems. The gauge integral is a generalization of the Riemann integral and the Lebesgue integral and applies to a much wider class of functions. In this paper, we formalize the
Zhiping Shi +6 more
doaj +1 more source
Chiral higher spin theories and self-duality
Journal of High Energy Physics, 2017 We study recently proposed chiral higher spin theories — cubic theories of interacting massless higher spin fields in four-dimensional flat space. We show that they are naturally associated with gauge algebras, which manifest themselves in several ...
Dmitry Ponomarev
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Regularity for non-unifomly elliptic systems and applications to some variational integrals
Electronic Journal of Differential Equations, 1995 minimizers of some variational integrals whose Euler equation is elliptic but not uniformly elliptic. This setting is also referred to as elliptic equations with $p,q$-growth conditions, following Marcellini.
Fracesco Leonetti, Chiara Musciano
doaj
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source