Results 41 to 50 of about 149,713 (251)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Estimation of the Reliability of a Stress–Strength System from Poisson Half Logistic Distribution
Entropy, 2020 This paper discussed the estimation of stress-strength reliability parameter R=P ...
Isyaku Muhammad +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
On Reliability in a Multicomponent Stress-Strength Model with Power Lindley Distribution
Revista Colombiana de EstadísticaIn this paper we study the reliability of a multicomponent stress-strength model assuming that the components follow power Lindley model. The maximum likelihood estimate of the reliability parameter and its asymptotic confidence interval are obtained ...
Abbas Pak +2 more
doaj +1 more source
Mathematics, 2023 It often takes a lot of time to conduct life-testing studies on products or components. Units can be tested under more severe circumstances than usual, known as accelerated life tests, to reduce the testing period.
Mazen Nassar +2 more
doaj +1 more source
Bayesian inference for orbital eccentricities
, 2012 Highest posterior density intervals (HPDI's) are derived for the true eccentricities of spectroscopic binaries with measured values e ~ 0. These yield upper limits when e is below the detection threshold e_th and seamlessly transform to upper and lower ...
Eastman +11 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Journal of Biostatistics and EpidemiologyIntroduction: Stress-strength models has achieved considerable attention in recent years due to its applicability in various areas like engineering, quality control, biology, genetics, medicine etc.
Sajad Rostamian
doaj +1 more source
A Bayesian Framework for Estimating Seismic Wave Arrival Time [PDF]
, 2019 Because earthquakes have a large impact on human society, statistical methods for better studying earthquakes are required. One characteristic of earthquakes is the arrival time of seismic waves at a seismic signal sensor.
Zhong, Hua
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source