Results 1 to 10 of about 6,760 (222)

Effect of chronic high‐altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders [PDF]

Experimental Physiology
High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular
Aymeric Paillisser, Julien Vincent Brugniaux, Florence Berquet, Jeremy De Abreu, Stephen Hogg, Emanuele Trucco, Martial Geiser, Tom Macgillivray, Aurélien Pichon, Paul Robach, Benoit Champigneulle, Samuel Verges, Christophe Chiquet   +12 more
doaj   +3 more sources

Effect of short-term supplemental oxygen therapy on 6-min walk distance in highlanders at risk for pulmonary hypertension: a randomised, crossover trial [PDF]

ERJ Open Research
Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high-altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves the 6-min walk
Dinah Hertig, Michael Furian, Julian Müller, Laura Mayer, Anna Titz, Mona Lichtblau, Alina Häfliger, Lena Reimann, Alessandro Vella, Maamed Mademilov, Adilet Omuralieva, Kay von Grünigen, Simon R. Schneider, Talant Sooronbaev, Silvia Ulrich   +14 more
doaj   +2 more sources

Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal [PDF]

Journal of Physiological Anthropology
Background Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia.
Hiroaki Arima, Takayuki Nishimura, Sweta Koirala, Masayuki Nakano, Hiromu Ito, Tomo Ichikawa, Kishor Pandey, Basu Dev Pandey, Taro Yamamoto   +8 more
doaj   +2 more sources

Gut microbiome alterations in pulmonary hypertension in highlanders and lowlanders

ERJ Open Research, 2023
Background Alterations in the gut microbiota have been observed in patients with pulmonary hypertension (PH), though whether the roles of the gut microbiota in PH at different altitudes are the same is unknown.
Wenxue Dong, Lifeng Ma, Qiumin Huang, Xu Yang, Zhendong Mei, Mengmeng Kong, Zhonghan Sun, Zhiying Zhang, Jing Li, Jiaojiao Zou, Dandan Chen, Yuxiang Dai, Daxin Zhou, Yan Zheng, Longli Kang   +14 more
doaj   +1 more source

Pulmonary haemodynamic response to exercise in highlanders versus lowlanders

ERJ Open Research, 2021
The aim of the study was to investigate the pulmonary haemodynamic response to exercise in Central Asian high- and lowlanders. This was a cross-sectional study in Central Asian highlanders (living >2500 m) compared with lowlanders (living
Silvia Ulrich, Stéphanie Saxer, Michael Furian, Patrick R. Bader, Paula Appenzeller, Philipp M. Scheiwiller, Maamed Mademilov, Ulan Sheraliev, Felix Tanner, Talantbek M. Sooronbaev, Konrad E. Bloch, Mona Lichtblau   +11 more
doaj   +1 more source

Circulating Microparticles Are Differentially Increased in Lowlanders and Highlanders with High Altitude Induced Pulmonary Hypertension during the Cold Season

Cells, 2022
The role of microparticles (MPs) and cold in high altitude pulmonary hypertension (HAPH) remains unexplored. We investigated the impact of long-term cold exposure on the pulmonary circulation in lowlanders and high-altitude natives and the role of MPs ...
Akylbek Sydykov, Aleksandar Petrovic, Abdirashit M. Maripov, Marija Gredic, Daniel Gerd Bermes, Nadira Kushubakova, Kubatbek Muratali Uulu, Christina Pilz, Meerim Cholponbaeva, Melis Duishobaev, Samatbek Satybaldyev, Nurgul Satieva, Argen Mamazhakypov, Meerim Sartmyrzaeva, Nazgul Omurzakova, Zhainagul Kerimbekova, Nursultan Baktybek, Cholpon Kulchoroeva, Oleg Pak, Lan Zhao, Norbert Weissmann, Sergey Avdeev, Leonid N. Maslov, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly, Akpay S. Sarybaev, Djuro Kosanovic   +26 more
doaj   +1 more source

The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the VEGFA gene in Sherpa highlanders [PDF]

PeerJ, 2022
Background Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, which may be achieved by mechanisms promoting microcirculatory blood flow and capillary density at high altitudes for restoring oxygen supply to tissues ...
Yunden Droma, Masayuki Hanaoka, Takumi Kinjo, Nobumitsu Kobayashi, Masanori Yasuo, Yoshiaki Kitaguchi, Masao Ota   +6 more
doaj   +2 more sources

Distinguishing feature of gut microbiota in Tibetan highland coronary artery disease patients and its link with diet

Scientific Reports, 2021
The prevalence of coronary artery disease (CAD) in Tibetan Highlanders is lower than that in plain-living individuals, but the mechanism still unclear. Gut microbiota (GM) disorder is considered one of the potential factors involved in the pathogenesis ...
Yulan Ma, Lulu Zhu, Zhijun Ma, Zhongshan Gao, Yumiao Wei, Youlu Shen, Lin Li, Xingli Liu, Ming Ren   +8 more
doaj   +1 more source

«Those fleeing from the cruelty of the owners should be taken under the protection of…»: prisoners and fugitives on the Kuban border in the 20s of the xix century (according to the State archive of Krasnodar region)

Гуманитарные и юридические исследования, 2022
The geopolitical realities that developed as a result of the victory of the Russian Empire in the war against Turkey in 1787 – 1791 carried new challenges for St. Petersburg related to the arrangement of the border along the Kuban River.
N. S. Tkalenko
doaj   +1 more source

Phenotypic differences between highlanders and lowlanders in Papua New Guinea.

PLoS ONE, 2021
ObjectivesAltitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock ...
Mathilde André, Nicolas Brucato, Sébastien Plutniak, Jason Kariwiga, John Muke, Adeline Morez, Matthew Leavesley, Mayukh Mondal, François-Xavier Ricaut   +8 more
doaj   +1 more source