Results 221 to 230 of about 5,670,099 (298)

Prevalence of thyroid dysfunction in highly active antiretroviral therapy -Exposed people living with human immunodeficiency virus. [PDF]

Thyroid Res
Adan AA, Ojuang RA, Nyanjom SG, Maina EK.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Secondary progression activity monitoring in MS despite an early highly active treatment the SPAM study. [PDF]

Eur J Neurol
Cohen M, Rollot F, Debouverie M, Zephir H, Vukusic S, De Seze J, Labauge P, Landes-Chateau C, Mondot L, Levraut M, Ruet A, Berger E, Laplaud D, Ciron J, Bourre B, Le Page E, Papeix C, Thouvenot E, Al Khedr A, Stankoff B, Pelletier J, Maillart E, Casez O, Moreau T, Defer G, Clavelou P, Cabre P, Moulin S, Neau JP, Zedet M, Hankiewicz K, Doghri I, Nasr HB, Pottier C, Magy L, Boulos DD, Heinzlef O, Camdessanche JP, Coustans M, Nifle C, Brassat D, Casey R, Lebrun-Frenay C, OFSEP and SFSEP study groups.   +43 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A Versatile Protein Scaffold Engineered for the Hierarchical Assembly of Robust and Highly Active Enzymes. [PDF]

Adv Sci (Weinh)
Meng Y, Peplowski L, Wu T, Gong H, Gu R, Han L, Xia Y, Liu Z, Zhou Z, Cheng Z.   +9 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Comparative effectiveness of disease-modifying therapies for highly active relapsing-remitting multiple sclerosis despite previous treatment - a systematic review and network meta-analysis. [PDF]

BMC Neurol
Köhler M, Paul F, Janke K, Sturtz S, Preukschat D, Ostlender S, Kerekes MF, Kaiser T.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

First Description of Simultaneous Sweet Syndrome and Tracheal Stenosis as Extraintestinal Manifestations in a Patient With Highly Active Ulcerative Colitis. [PDF]

ACG Case Rep J
Alrasheed H, Kahraman O, Markert E, Kim OC, Pelzer C, Boggian K, Brand S, Truniger S.   +7 more
europepmc   +1 more source