Results 241 to 250 of about 8,362,360 (307)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Paramagnetic Rim Lesions in Highly Active Multiple Sclerosis at the Time of Disease Diagnosis: Prevalence Data and Clinical Implications. [PDF]

Eur J Neurol
Cicia A, Lucchini M, Di Fiore G, Cefaro LA, Bianco A, Nociti V, Carlomagno V, Gaudino S, Mirabella M.   +8 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Valorization of Silicon-Rich Solid Waste into Highly Active Silicate Adsorbents for Heavy Metal Removal. [PDF]

Toxics
Jiang S, Huang X, Chen H, Miao J, Xiao X, Zhuo Y, Li X, Chen Y.   +7 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Low-spin state design of highly active diatomic catalysts for oxygen reduction reaction. [PDF]

Natl Sci Rev
Li H, Li Z, Zeng J, Liu Z, Di S, Li X, Wang J, Wang S, Li L.   +8 more
europepmc   +1 more source

<i>Pseudomonas aeruginosa</i> Cryptic Prophage Endolysin Is a Highly Active Muramidase. [PDF]

Biochemistry
Thorén Edvardsen PK, Englund AN, Kjendseth Ro̷hr Å, Mesnage S, Vaaje-Kolstad G.   +4 more
europepmc   +1 more source

Effectiveness of Rituximab in rElapsiNg Multiple SclErosis previously treated with hiGhly-Active Disease modifying thErapies (RENEGADE study). [PDF]

J Neurol
Chisari CG, Lo Fermo S, Di Sapio A, Amato MP, Salemi G, Pesci I, Curti E, Ferraro D, Lugaresi A, Massacesi L, Inglese M, Gazzola P, Realmuto S, Fioretti C, Aguglia U, Montepietra S, Filippi M, Patti F, Italian Multiple Sclerosis and Related Disorders Register Group.   +18 more
europepmc   +1 more source

Clinical effects of adjunctive spleen- and kidney-invigorating Chinese herbal therapy combined with highly active antiretroviral treatment on immune recovery and nutritional status in people living with HIV. [PDF]

Malawi Med J
Zhang L, Ren Y, Zhang Z, Zhang B, Xu C.
europepmc   +1 more source