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A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

Viruses, 2021
By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Carmen María González-Domenech, Isabel Pérez-Hernández, Cristina Gómez-Ayerbe, Isabel Viciana Ramos, Rosario Palacios-Muñoz, Jesús Santos   +5 more
doaj   +1 more source

Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial

Frontiers in Immunology, 2021
IntroductionFunctional cure has been proposed as an alternative to lifelong antiretroviral therapy and therapeutic vaccines represent one of the most promising approaches.Materials and MethodsWe conducted a double-blind randomized placebo-controlled ...
Lorna Leal, Lorna Leal, Lorna Leal, Elvira Couto, Elvira Couto, Sonsoles Sánchez-Palomino, Núria Climent, Irene Fernández, Irene Fernández, Laia Miralles, Yolanda Romero, Yolanda Romero, Tania González, Maria José Maleno, Blanca Paño, Judit Pich, Carlos Nicolau, Carlos Nicolau, José Maria Gatell, José Maria Gatell, José Maria Gatell, José Maria Gatell, Montserrat Plana, Montserrat Plana, Felipe García, Felipe García, Felipe García, the DCV3-RISVAC04 Study Group, Lorna Leal, Irene Fernández, Elvira Couto, Yolanda Romero, Laia Miralles, Carmen Hurtado, Núria Climent, Tania González, Maria José Maleno, Judit Pich, Laura Burunat, Joan Albert Arnaiz, Blanca Paño, Carlos Nicolau, Rafael Salvador, Elisabet Farré, Sonsoles Sánchez-Palomino, José Maria Gatell, Montserrat Plana, Felipe García, Berta Torres, Constanza Lucero, Montserrat Laguno, María Martínez-Rebollar, Ana González-Cordón, John Rojas, Alexy Inciarte, Lorena de la Mora, Josep Mallolas, Esteban Martínez, José Luis Blanco, Unai Perpiñá, Josep Canals, Raquel Martín, Florencia Echeverry, Cristina Xufré, Cristina Rovira, Marta Sala, Amparo Tricas   +66 more
doaj   +1 more source

Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection

Frontiers in Immunology, 2022
Interactions between T follicular helper (Tfh) cells and germinal center B cells are essential for the differentiation of B cells and specific antibody responses against HIV-1 infection.
Xiaofan Lu, Xin Zhang, Allen Ka Loon Cheung, Christiane Moog, Huan Xia, Zhen Li, Rui Wang, Yunxia Ji, Wei Xia, Zhiying Liu, Lin Yuan, Xiuwen Wang, Hao Wu, Tong Zhang, Bin Su   +14 more
doaj   +1 more source

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. [PDF]

, 2010
OBJECTIVES: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect of variation in 2 genes that encode products critical to HIV pathogenesis and disease progression: CD4 and CD209.
Aaby, Peter, Bisseye, Cyrille, Edwards, Todd L, Hennig, Branwen J, Hill, Adrian V, Jaye, Assan, Kaye, Steve, Novelli, Giuseppe, Schim van der Loeff, Maarten F, Scott, William K, Sirugo, Giorgio, Tacconelli, Alessandra, Velez-Edwards, Digna R, Whittle, Hilton C, Williams, Scott M   +14 more
core   +8 more sources

Acceptability and usability of HIV self-tests in two European countries: findings from surveys of clients at non-governmental organisations in Lithuania and Italy

BMC Infectious Diseases, 2021
Background Uptake of HIV self-tests (HIVST) remains low in Europe. We conducted two separate surveys to understand facilitators and barriers to the use of HIVST in two European countries, as part of the EU INTEGRATE Joint Action.
Sophie G. Nash, Manuel Maffeo, Giedrius Likatavicius, Lella Cosmaro, Kestutis Rudaitis, Aleksandras Lapsinov, Qudsia Enayat, Valerie Delpech, Meaghan Kall   +8 more
doaj   +1 more source

Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine

Chinese Medical Journal, 2023
. Background:. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity.
Junyan Jin, Xiuwen Wang, Yongzheng Li, Xiaodong Yang, Hu Wang, Xiaoxu Han, Jin Sun, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Tong Zhang, Hao Wu, Xin Zhang, Bin Su, Yanjie Yin   +15 more
doaj   +1 more source

Latent tuberculosis screening and treatment in HIV: highly acceptable in a prospective cohort study

ERJ Open Research, 2022
Background People living with HIV (PLWH) are at increased risk of re-activation of latent tuberculosis infection (LTBI). Although UK and international guidelines identify this group as a priority for LTBI screening and treatment, data on attitudes of ...
Helena A. White, Hajra Okhai, Amandip Sahota, John Maltby, Iain Stephenson, Hemu Patel, Philip M. Hefford, Martin J. Wiselka, Manish Pareek   +8 more
doaj   +1 more source

Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure

Chinese Medical Journal, 2023
. Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li, Hu Wang, Na Guo, Bin Su, Olivier Lambotte, Tong Zhang, Yanjie Yin   +6 more
doaj   +1 more source

Awareness and Use of Post-exposure Prophylaxis for HIV Prevention Among Men Who Have Sex With Men: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2022
Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors.
Junyan Jin, Runsong Sun, Tingting Mu, Taiyi Jiang, Lili Dai, Hongyan Lu, Xianlong Ren, Jing Chen, Jingrong Ye, Lijun Sun, Hao Wu, Tong Zhang, Huachun Zou, Bin Su   +13 more
doaj   +1 more source

Exploring the biological function of immune cell-related genes in human immunodeficiency virus (HIV)-1 infection based on weighted gene co-expression network analysis (WGCNA)

BMC Medical Genomics, 2022
Background Acquired immunodeficiency syndrome (AIDS) is a chronic infectious disease characterized by consistent immune dysfunction. The objective of this study is to determine whether immune cell-related genes can be used as biomarkers for the ...
Ruojing Bai, Zhen Li, Shiyun Lv, Wei Hua, Lili Dai, Hao Wu   +5 more
doaj   +1 more source