Results 41 to 50 of about 937,893 (307)

Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity

Frontiers in Immunology, 2022
Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the ...
Shuang Li, Shuang Li, Xiaodong Yang, Xiaodong Yang, Christiane Moog, Christiane Moog, Hao Wu, Hao Wu, Bin Su, Bin Su, Tong Zhang, Tong Zhang   +11 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Increased mortality among Indigenous persons during and after release from prison in New South Wales

Australian and New Zealand Journal of Public Health, 2012
Objective: To estimate the overall and cause specific mortality of Aboriginal offenders in New South Wales (NSW), Australia. Methods: The study cohort consisted of all Aboriginal men and women aged 18 years and older who had experienced full‐time ...
Azar Kariminia, Tony Butler, Jocelyn Jones, Matthew Law   +3 more
doaj   +1 more source

Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission

Frontiers in Immunology, 2021
BackgroundThe vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune ...
Jammy Mariotton, Anette Sams, Emmanuel Cohen, Alexis Sennepin, Gabriel Siracusano, Francesca Sanvito, Lars Edvinsson, Nicolas Barry Delongchamps, Marc Zerbib, Lucia Lopalco, Morgane Bomsel, Yonatan Ganor   +11 more
doaj   +1 more source

Declining HIV-1 Prevalence and Incidence among Police Officers - A potential Cohort for HIV Vaccine Trials, in Dar es Salaam, Tanzania. [PDF]

, 2013
A safe effective and affordable HIV vaccine is the most cost effective way to prevent HIV infection worldwide. Current studies of HIV prevalence and incidence are needed to determine potentially suitable cohorts for vaccine studies.
Bo Hejdeman, EF Lyamuya, Eric Aris, Eric Sandstrom, J Esparza, J Esparza, M Bakari, M Bakari, Mohamed Janabi, Muhammad Bakari, Patricia J Munseri, PJ Munseri, S Aboud, S Rerks-Ngarm, Said Aboud, Tanzania Commission for AIDS (TACAIDS) ZACZ, National Bureau of Statistics (NBS), Office of Chief Government Statistician (OCGS), and Macro International Inc, UNAIDS, UNAIDS   +17 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load

Cell Reports, 2020
Summary: HIV infection predisposes latent tuberculosis-infected (LTBI) subjects to active TB. This study is designed to determine whether HIV infection of LTBI subjects compromises the balanced Mycobacterium tuberculosis (Mtb)-specific T helper 17 (Th17)
Srabanti Rakshit, Nitin Hingankar, Shuba Varshini Alampalli, Vasista Adiga, Bharath K. Sundararaj, Pravat Nalini Sahoo, Greg Finak, Anto Jesuraj Uday Kumar J, Chirag Dhar, George D’Souza, Rashmi Govind Virkar, Manisha Ghate, Madhuri R. Thakar, Ramesh S. Paranjape, Stephen C. De Rosa, Tom H.M. Ottenhoff, Annapurna Vyakarnam   +16 more
doaj   +1 more source

Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers

BMC Medicine, 2023
Background Healthcare workers’ (HCW) well-being has a direct effect on patient care. However, little is known about the prevalence and patterns of long-term medical conditions in HCWs, especially those from ethnic minorities.
Winifred Ekezie, Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Joshua Nazareth, Daniel Pan, Shirley Sze, Luke Bryant, Katherine Woolf, Laura J. Gray, Kamlesh Khunti, Manish Pareek, on behalf of the UK-REACH study collaborative group   +12 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

Frontiers in Immunology, 2018
The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their in vitro neutralizing activity engaging their Fab region.
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Marwa Khamassi, Marwa Khamassi, Marwa Khamassi, Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +14 more
doaj   +1 more source