Results 261 to 270 of about 5,670,099 (298)
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Science, 2007
The observation that biological activity in eddies can be very high may help explain why measurements of ocean productivity have varied widely.
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The observation that biological activity in eddies can be very high may help explain why measurements of ocean productivity have varied widely.
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HIGHLY ACTIVE ANTICANCER CURCUMIN ANALOGUES
2007Curcumin, a compound in the human food supply, represents a near-perfect starting point for drug discovery. Consequently, a number of research groups have taken the natural product as a starting point to prepare and biologically evaluate a wide variety of curcumin analogues.
Cara A, Mosley +2 more
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Highly Active Myeloid Therapy for Cancer
ACS Nano, 2023Tumor-associated macrophages (TAM) interact with cancer and stromal cells and are integral to sustaining many cancer-promoting features. Therapeutic manipulation of TAM could therefore improve clinical outcomes and synergize with immunotherapy and other cancer therapies.
Ina R. Fredrich +5 more
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A highly active synthetic mammalian retrotransposon
Nature, 2004LINE-1 (L1) elements are retrotransposons that comprise large fractions of mammalian genomes. Transcription through L1 open reading frames is inefficient owing to an elongation defect, inhibiting the robust expression of L1 RNA and proteins, the substrate and enzyme(s) for retrotransposition.
Jeffrey S, Han, Jef D, Boeke
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Phosphorylation Organocatalysts Highly Active by Design
Organic Letters, 2020The activity of nucleophilic organocatalysts for alcohol/phenol phosphorylation was enhanced through attaching oligoether appendages to a benzyl substituent on imidazole- or aminopyridine-based active units, presumably because of stabilizing n-cation interactions of the ethereal oxygens with the positively charged aza-heterocycle in the catalytic ...
Amit Fallek +4 more
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Highly efficient catalase activity of metallocorroles
Chemical Communications, 2010The iron(iii) complex of a bipolar and amphiphilic corrole, which binds strongly to proteins and undergoes protein-mediated cellular uptake, catalyzes the decomposition of hydrogen peroxide faster (k(cat) = 6400 M(-1) s(-1)) and more efficiently (turnover frequency >120 s(-1)) than previously reported synthetic compounds with catalase-like activity.
Atif, Mahammed, Zeev, Gross
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Highly Sensitive Electrochemical Methyltransferase Activity Assay
Analytical Chemistry, 2014A simple and highly sensitive electrochemical DNA methyltransferase (MTase) activity assay is presented in this report. The assay employs the electrocatalytic oxidation of ascorbic acid (AA) by a threading intercalator (N,N'-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide (PIND) functionalized with electrocatalytic redox Os(bpy)2Cl(+) moieties (PIND-
Deng, H., Yang, X., Yeo, S.P.X., Gao, Z.
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Highly active antimycobacterial derivatives of benzoxazine
Bioorganic & Medicinal Chemistry, 2010New 3-(4-alkylphenyl)-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii.
Eva, Petrlíková +7 more
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Highly active multiple sclerosis: An update
Multiple Sclerosis and Related Disorders, 2019Multiple sclerosis (MS) is the most prevalent chronic inflammatory disease of the central nervous system (CNS), affecting more than 2 million people worldwide. It is characterized by brain and spinal cord involvement. There are the relapsing remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS) phenotypes.
Cindy Díaz +2 more
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Highly Active Low Magnesium Hammerhead Ribozyme
The Journal of Biochemistry, 2009Hammerhead (HH) ribozymes can be used for highly specific inhibition of gene expression through the degradation of target mRNA. In vitro experiments with minimal HH domains demonstrated that the efficiency of catalysis is highly dependent on concentration of magnesium ions. Optimal ion requirements for HH-catalysed RNA cleavage are far from these found
Agnieszka, Fedoruk-Wyszomirska +4 more
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