Results 61 to 70 of about 13,516,968 (375)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Highly Active, Entirely Biobased Antimicrobial Pickering Emulsions

ChemMedChem, 2021
AbstractWe present the development of surfactant‐free, silica‐free and fully biobased oil‐in‐water antimicrobial Pickering emulsions, based on the self‐assembly of β‐cyclodextrin and phytoantimicrobial oils (terpinen‐4‐ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio‐based drug to treat fungal infection, but is less ...
Leclercq, Loïc, Tessier, Jérémie, Nardello-Rataj, Véronique, Schmitzer, Andreea‐ruxandra   +3 more
openaire   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Case report: A highly active refractory myasthenia gravis with treatment of telitacicept combined with efgartigimod

Frontiers in Immunology
There is always a lack of effective treatment for highly active refractory generalized myasthenia gravis (GMG). Recently, telitacicept combined with efgartigimod significantly reduces circulating B cells, plasma cells, and immunoglobulin G, which brings ...
Chaoyue Zhang, Yangtao Lin, Qianjin Kuang, Hongjin Li, Qilong Jiang, Xiaojun Yang   +5 more
doaj   +1 more source

Antiretroviral agents against human immunodeficiency virus

DST, 2022
Introduction: Since its discovery in the 1980s, the human immunodeficiency virus (HIV) has been the target of many studies. Nowadays, estimates show that 36.7 million people are infected with HIV worldwide.
Ingrid Barcelos de Oliveira, Claudio Cesar Cirne Santos, Izabel Christina Nunes de Palmer Paixão, Caroline de Souza Barros, Rosa Teixeira Pinho   +4 more
doaj  

Life, Death and Preferential Attachment [PDF]

, 2004
Scientific communities are characterized by strong stratification. The highly skewed frequency distribution of citations of published scientific papers suggests a relatively small number of active, cited papers embedded in a sea of inactive and uncited ...
A. D Jackson, B Lautrup, Cole J. R., de Solla Price Derek, Derek de Solla Price, Matthew, Merton R. K., S Lehmann, Simon H. A.   +8 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Development and validation of a clinical score for prognosis stratification in patients requiring antiretroviral therapy in sub-Saharan Africa: a prospective open cohort study

The Pan African Medical Journal, 2011
BACKGROUND: Mortality rates among patients initiating antiretroviral therapy (ART) in sub-Saharan Africa continue high. Also HIV treatment services from the region are affronting the challenges of been attending more patients than never. In this scenario,
Rivero Gerardo, Perez Dayana
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Bone Disease in HIV: Need for Early Diagnosis and Prevention

Life
The transformation of HIV into a manageable chronic condition has unveiled new clinical challenges associated with aging-related pathologies, including bone disease. This review explores the intricate relationship between HIV, antiretroviral therapy (ART)
Georgios Schinas, Ioannis Schinas, Georgios Ntampanlis, Eleni Polyzou, Charalambos Gogos, Karolina Akinosoglou   +5 more
doaj   +1 more source