Results 31 to 40 of about 1,023,504 (281)
Scarce Sample-Based Reliability Estimation and Optimization Using Importance Sampling
Mathematical and Computational Applications, 2022 Importance sampling is a variance reduction technique that is used to improve the efficiency of Monte Carlo estimation. Importance sampling uses the trick of sampling from a distribution, which is located around the zone of interest of the primary ...
Kiran Pannerselvam +2 more
doaj +1 more source
Estimates for the Hill Operator, I
Journal of Differential Equations, 2000 The author studies one-dimensional Schrödinger operators \(-d^2/dx^2 + q(x)\) with periodic potentials \(q(x)=q(x+1)\), normalized by \(\int_0^1 q(x) dx = 0\). He proves various estimates involving the \(L_2(0,1)\) norm of the potential and some spectral data. Typical of his results is the following: Let \(\gamma = (\gamma_n)\) be a sequence of the gap
openaire +2 more sources
A New Class of Reduced-Bias Generalized Hill Estimators
MathematicsThe estimation of the extreme value index (EVI) is a crucial task in the field of statistics of extremes, as it provides valuable insights into the tail behavior of a distribution.
Lígia Henriques-Rodrigues +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Journal of Economic and Financial Sciences, 2019 Orientation: Exchange market pressure (EMP) is the selling pressure of domestic currency or excess demand needed for foreign currency. Research purpose: The purpose of this study was to analyse EMP using extreme value theory (EVT) and to compare two ...
Pieter-Henk Boer +3 more
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Harmony Search Algorithm approach for optimizing traffic signal timings
Promet (Zagreb), 2013 In this study, a bi-level formulation is presented for solving the Equilibrium Network Design Problem (ENDP). The optimisation of the signal timing has been carried out at the upper-level using the Harmony Search Algorithm (HSA), whilst the traffic ...
Mauro Dell'Orco +2 more
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The Astrophysical Journal, 2023 We propose a cross-internal linear combination (cross-ILC) approach to measure the small-scale cosmic microwave background (CMB) anisotropies robustly against the contamination from astrophysical signals.
Srinivasan Raghunathan, Yuuki Omori
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
State Estimation and Model-Based Control of a Pilot Anaerobic Digestion Reactor
Journal of Control Science and Engineering, 2014 A state estimator and various model-based control systems have been designed for a real anaerobic digestion (AD) pilot reactor fed with dairy manure. The model used is a modified Hill model which is a relatively simple dynamical AD process model.
Finn Haugen, Rune Bakke, Bernt Lie
doaj +1 more source