Results 41 to 50 of about 8,231 (239)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Consistency of Hill's estimator for dependent data [PDF]
Journal of Applied Probability, 1995 Consider a sequence of possibly dependent random variables having the same marginal distribution F, whose tail 1−F is regularly varying at infinity with an unknown index − α < 0 which is to be estimated. For i.i.d. data or for dependent sequences with the same marginal satisfying mixing conditions, it is well known that Hill's estimator is ...
Resnick, Sidney, Stărică, Cătălin
openaire +2 more sources
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Improving Second Order Reduced Bias Extreme Value Index Estimation
Revstat Statistical Journal, 2007 Classical extreme value index estimators are known to be quite sensitive to the number k of top order statistics used in the estimation. The recently developed second order reduced-bias estimators show much less sensitivity to changes in k. Here, we are
M. Ivette Gomes +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Atmosphere, 2017 Although precipitation extremes exert a major influence on populations and the environment, trend analysis for the entire Qinghai-Tibetan plateau (QTP) has not previously been undertaken.
Genbatu Ge +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Controlling for Differential Regression-To-The-Mean via Propensity Scores: A Simulation Study
Clinical Epidemiology, 2023 Chase D Latour,1,2 Leah J McGrath,2 Mary Clouser,3 Carrie Nielson,3 Ying Yu,2 Akhila Balasubramanian,3 Alexander Breskin,1,2 M Alan Brookhart2,4 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 2Target RWE ...
Latour CD +7 more
doaj
Value-at-Risk Estimation and the Port Mean-of-Order-P Methodology
Revstat Statistical Journal, 2017 In finance, insurance and statistical quality control, among many other areas of appli[1]cation, a typical requirement is to estimate the value-at-risk (VaR) at a small level q, i.e. a high quantile of probability 1 −q, a value, high enough, so that the
Fernanda Figueiredo +2 more
doaj +1 more source