Results 101 to 110 of about 56,651 (307)
Advanced Science, EarlyView.Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
EMG‐Driven Telemetry and Inference System for Fish: Pose Reconstruction and Flow Sensing
Advanced Intelligent Systems, EarlyView.This work introduces an electromyography (EMG)‐driven telemetry framework that reconstructs body pose and infers hydrodynamic conditions in freely swimming fish. A custom 16‐channel archival system records intramuscular EMG, enabling deep‐learning models to decode joint kinematics, classify flow regimes, and reveal channel‐efficient sensing strategies.
Rahdar Hussain Afridi +7 more
wiley +1 more source
Pedal press task for skilled hindlimb movements.
, 2012 Rats were trained to press a floor-mounted pedal with their hindlimb. (A) Schematic of the skilled hindlimb task. (1) After a randomized period of 3–5 seconds, the chime was sounded, cueing (2) the press and release, which, if completed within three ...
Robert D. Flint (107040) +3 more
core +1 more source
A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis
Animal Models and Experimental Medicine, EarlyView.A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu +6 more
wiley +1 more source
Nature CommunicationsThe hindlimb and external genitalia of present-day tetrapods are thought to derive from an ancestral common primordium that evolved to generate a wide diversity of structures adapted for efficient locomotion and mating in the ecological niche occupied by
Anastasiia Lozovska +7 more
doaj +1 more source
Effects of ovariectomy and hindlimb unloading on skeletal muscle
, 1998 Female rats (7–8 mo old, n = 40) were randomly placed into the intact control (Int) and ovariectomized control (Ovx) groups. Two weeks after ovariectomy, animals were further divided into intact 2-wk hindlimb unloaded (Int-HU) and ovariectomized hindlimb
Marybeth Brown +2 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source
Rangifer, 2019 Phalanges are a great untapped resource in the zooarchaeology of Rangifer tarandus. The utilization of this resource, however, is constrained by a current inability to consistently differentiate fore- from hindlimb phalanges in a mixed assemblage.
Emily H Hull
doaj +1 more source
Vacuum-assisted perfusion of the dog hindlimb
, 1986 A method for rapidly changing perfusion pressure to the relatively intact dog hindlimb using vacuum assistance is proposed and demonstrated. The hindlimb of an anesthetized dog is inserted into a rigid sealed enclosure for application of a partial ...
V. J. Bagnato +2 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith +6 more
wiley +1 more source