Results 131 to 140 of about 61,808 (305)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb

, 1994
Lactate uptake by skeletal muscle occurs under diverse conditions, including hypoxia and electrical stimulation. A possible metabolic fate of lactate in resting muscle is its conversion to pyruvate followed by carboxylation to malate in the cytosolic ...
E. Fernandez, R. Kiiski, J. J. Ronco, G. Arbelaez, G. Gutierrez, F. J. Hurtado, S. Chakravarthy   +6 more
core   +1 more source

Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat

Journal of Physiological Sciences
Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality, but increases in response to noxious ...
Ryota Tokunaga, Hideshi Shibata, Mieko Kurosawa   +2 more
doaj   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Role of adrenergic receptors in the caffeine-induced increase in glucose uptake by the canine hindlimb [PDF]

, 2009
The present study was designed to investigate the effects of alpha and beta adrenergic receptor blockers on caffeine-induced increase in canine hindlimb glucose uptake. The study was carried out on fasted male anaesthetized dogs divided into five groups (
Salahdeen, H. M., Alada, A.R.A.
core   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

Focal Traumatic Brain Injury Impairs the Integrity of the Basement Membrane of Hindlimb Muscle Fibers Revealed by Extracellular Matrix Immunoreactivity

Life
Traumatic brain injury (TBI) stands as a prominent global cause of disability, with motor deficits being a common consequence. Despite its widespread impact, the precise pathological mechanisms underlying motor deficits after TBI remain elusive.
Mette Albæk Kristensen, Karen Kalhøj Rich, Tobias Christian Mogensen, Andreas Malmquist Damsgaard Jensen, Åsa Fex Svenningsen, Mengliang Zhang   +5 more
doaj   +1 more source

A second species of non‐crocodyliform crocodylomorph from the Late Triassic fissure deposits of southwestern UK: Implications for locomotory ecological diversity in Saltoposuchidae

The Anatomical Record, EarlyView.
Abstract The Late Triassic–Early Jurassic fissures of the Bristol Channel area (southwest England and south Wales) are renowned for their diverse vertebrate faunas. These assemblages have yielded an array of predominantly small‐bodied forms that are crucial to our understanding of the early evolution of several major tetrapod clades.
Ewan H. Bodenham, Stephan N. F. Spiekman, Susannah C. R. Maidment, Paul Upchurch, Philip D. Mannion   +4 more
wiley   +1 more source

Quantitative muscle architecture in large carnivorous marsupials (Marsupialia: Dasyuridae) and links to substrate use and prey processing

The Anatomical Record, EarlyView.
Abstract The Dasyurid species Sarcophilus harrisii, Dasyurus maculatus, and Dasyurus viverrinus, occupying diverse ecological niches and forming a guild structure in Tasmania, provide a basis for examining the roles of various forelimb muscle groups in prey capture and locomotion.
Riya G. Bidaye, Samuel H. Frenkel, David P. Hocking, Alistair R. Evans, Justin W. Adams   +4 more
wiley   +1 more source