Results 161 to 170 of about 56,651 (307)

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source

Single-cell profiling unveils key regulators of skeletal stem cells in chicken and human embryonic limb development. [PDF]

PLoS One
Zhao R, Jian Z, Yang F, Wang K, Liu L, Xu Z, Jia J, Dou T, He X.   +8 more
europepmc   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti-GDF-15 Antibody-Based Combination Therapies. [PDF]

J Cachexia Sarcopenia Muscle
Breen DM, Joaquim S, Paulhus BL, Bennett D, Bernardo B, Collins S, Esquejo RM, Kim-Muller JY, Lin L, Peloquin M, Wu Z, Qiao S, Stansfield JC, Zhang BB, Rossulek MI.   +14 more
europepmc   +1 more source

Laser neoureterocystostomy to treat ectopic ureters

Equine Veterinary Journal, EarlyView.
Abstract Background Ureteral ectopia is an uncommon but clinically important congenital abnormality in horses. If left untreated, it can lead to persistent dermatitis, urinary tract infections, and failure to thrive. Surgical correction is necessary, but traditional approaches have produced mixed results with high morbidity.
Caitlin Smith, Eric J. Parente
wiley   +1 more source

In Vivo Extracellular Recording Reveals Bidirectional Changes in Neuronal Activity in the Rat Spinal Dorsal Horn After Hindlimb Ischemia-Reperfusion. [PDF]

Int J Mol Sci
Uta D, Takeuchi K, Yano K, Fukano K, Minami T, Ito A.   +5 more
europepmc   +1 more source

Similar locomotor patterns across Quarter Horse disciplines inform lameness assessment

Equine Veterinary Journal, EarlyView.
Abstract Background Lineage‐based selection is central to the Quarter Horse industry and is often justified by the assumption that morphology determines locomotor function. However, objective evidence linking static conformation to discipline‐specific locomotor behaviour under standardised conditions remains limited.
Renata Farinelli de Siqueira, Lavínia Andressa Brito, Isabela Marques de Figueiredo, Ana Clara Rocha dos Santos, Larissa Santos dos Anjos   +4 more
wiley   +1 more source

Cyclogram analysis of canine gait: quantifying inter-joint coordination and clinical utility in rehabilitation. [PDF]

Front Vet Sci
Yoshikawa K, Iwata T, Tomura S, Fujita A, Haii K, Edamura K, Shimada A, Kadosawa T.   +7 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Comparative analysis of clearing methods for 3D imaging of the vasculature in mineralized mouse tissues. [PDF]

iScience
Ishola AO, Pillai A, Ahn T, RE-JOIN Consortium, Hsu CW, Lee B, Haelterman N, Wythe JD.   +7 more
europepmc   +1 more source