Results 201 to 210 of about 56,651 (307)

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade   +7 more
wiley   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda   +5 more
wiley   +1 more source

An unusual presentation of osteochondrosis in the elbows and tarsi of a Friesian colt

open access: yesEquine Veterinary Education, EarlyView.
Summary This case report describes the clinical, diagnostic imaging results and post‐mortem findings in a foal that underwent reassessment following surgical management of angular limb deformities (ALD) and acute onset of gait abnormalities. Upon presentation, the foal showed an abnormal stiff gait characterised by bilateral medial limb collapse during
A. Torrent‐Crosa   +3 more
wiley   +1 more source

Disposable negative pressure wound therapy system enhances punch graft acceptance in equine distal limb wounds

open access: yesEquine Veterinary Education, EarlyView.
Summary This case series describes the use of a disposable, canister‐free negative pressure wound therapy (NPWT) system (PICO®) in combination with punch grafting for the treatment of distal limb wounds in three horses. Each horse presented with complex traumatic injuries resulting in delayed or inadequate healing of distal limb wounds.
M. Schnierer   +2 more
wiley   +1 more source

Gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle atrophy. [PDF]

open access: yesJ Physiol
Xu Y   +13 more
europepmc   +1 more source

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