Results 231 to 240 of about 61,808 (305)

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Therapeutic Efficacy of Combined Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma Therapy in a Rat Model of Acute Achilles Tendinopathy. [PDF]

Orthop J Sports Med
Terakawa F, Mukai M, Ochiai N, Hashimoto E, Hattori F, Yamakawa N, Sawada R, Yamada Y, Tajiri I, Ohtori S.   +9 more
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

FLCN Multi-Exon Deletion in a Chihuahua With Renal Cysts and Nodular Dermatofibrosis. [PDF]

Anim Genet
Schneiter M, Selz J, Jonker J, Dettwiler M, Jagannathan V, Leeb T, Maina E.   +6 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Neural Network Connection Characteristics Between Motor Cortex and Spinal Cord During Rat Bipedal Walking. [PDF]

CNS Neurosci Ther
Xi P, Lyu X, He J, Tang R, Lang Y.
europepmc   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Surgical Management of Extensive Urine Extravasation Resulting in Urethrocutaneous Fistulation and Soft Tissue Necrosis of the Femoral Region Secondary to Pelvic Urethral Rupture in Two Cats. [PDF]

Animals (Basel)
Kim D, Koo GJ, Lee SK, Koo Y, Jang M, Yun SH, Kwon YS, Kang J.   +7 more
europepmc   +1 more source

Biomechanical effects of equine training aids: A systematic review

Equine Veterinary Education, EarlyView.
Summary Equine training aids, including auxiliary reins such as draw reins, Pessoa‐type systems and side reins, are widely used during lungeing and ridden exercise to improve posture, back engagement and movement quality. Despite their extensive practical application, the biomechanical effects of these devices remain poorly defined and are often ...
R. F. Siqueira, I. M. Figueiredo
wiley   +1 more source

Hindlimb Representation in the Spiny Mouse Sensorimotor Cortex. [PDF]

J Comp Neurol
Beljajev A, Veshchitskii A, Mikhalkin A, Shkorbatova P, Merkulyeva N.   +4 more
europepmc   +1 more source