FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension [PDF]
BMC Musculoskeletal Disorders, 2007 Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave +4 more
doaj +6 more sources
Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response [PDF]
Physiological Reports, 2021 Ground‐based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold‐standard and allows researchers to study ...
Marie Mortreux +6 more
doaj +6 more sources
Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension [PDF]
Brazilian Journal of Medical and Biological Research, 2019 The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days.
G.N. Marzuca-Nassr +7 more
doaj +4 more sources
The Effects of Progressive Resistance Exercise on Recovery Rate of Bone and Muscle in a Rodent Model of Hindlimb Suspension [PDF]
Frontiers in Physiology, 2018 Purpose: This study aimed to examine the exercise-mediated musculoskeletal recovery following hindlimb suspension (HS) in order to identify whether bone modeling and muscle hypertrophy would eventuate in a synchronized manner during recovery stage ...
Ho-young Lee, Hojun Lee, Wook Song
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Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections. [PDF]
PLoS ONE, 2014 A major risk of extended space travel is the combined effects of weightlessness and radiation exposure on the immune system. In this study, we used the hindlimb suspension model of microgravity that includes the other space stressors, situational and ...
Minghong Li +6 more
doaj +6 more sources
The combined effects of X-ray radiation and hindlimb suspension on bone loss. [PDF]
J Radiat Res, 2014 Outer space is a complex environment with various phenomena that negatively affect bone metabolism, including microgravity and highly energized ionizing radiation. In the present study, we used four groups of male Wistar rats treated with or without four-week hindlimb suspension after 4 Gy of X-rays to test whether there is a combined effect for ...
Xu D +7 more
europepmc +7 more sources
Effect of solar particle event radiation and hindlimb suspension on gastrointestinal tract bacterial translocation and immune activation. [PDF]
PLoS ONE, 2012 The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity, stress, radiation, disturbance of circadian rhythms, and altered nutritional intake.
Yu Zhou +7 more
doaj +4 more sources
The Oxidative Phosphorylation and Cytoskeleton Proteins of Mouse Ovaries after 96 Hours of Hindlimb Suspension [PDF]
Life, 2023 The purpose of this study was to assess oxidative phosphorylation (OXPHOS) in mouse ovaries, determine the relative content of proteins that form the respiratory chain complexes and the main structures of the cytoskeleton, and determine the mRNA of the ...
Elena Yu. Gorbacheva +3 more
doaj +2 more sources
Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice [PDF]
npj Microgravity, 2023 Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating in long-duration spaceflight.
Andrea M. Hanson +6 more
doaj +2 more sources
Effects of resveratrol on the recovery of muscle mass following disuse in the plantaris muscle of aged rats. [PDF]
PLoS ONE, 2013 Aging is associated with poor skeletal muscle regenerative ability following extended periods of hospitalization and other forms of muscular disuse. Resveratrol (3,5,4'-trihydroxystilbene) is a natural phytoalexin which has been shown in skeletal muscle ...
Brian T Bennett +2 more
doaj +4 more sources