Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response [PDF]
Physiological Reports, 2021 Ground‐based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold‐standard and allows researchers to study ...
Marie Mortreux +6 more
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Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice [PDF]
npj Microgravity, 2023 Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating in long-duration spaceflight.
Andrea M. Hanson +6 more
doaj +5 more sources
Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model [PDF]
Journal of Orthopaedic Translation, 2017 Background/Objective: The participation of sensory neural regulation in bone metabolism has been widely studied. However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear.
Zong-Kang Zhang +3 more
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TFAM overexpression diminishes skeletal muscle atrophy after hindlimb suspension in mice. [PDF]
Arch Biochem Biophys, 2019 The present study aims to investigate if overexpressing the mitochondrial transcription factor A (TFAM) gene in a transgenic mouse model diminishes soleus and gastrocnemius atrophy occurring during hindlimb suspension (HLS). Additionally, we aim to observe if combining exercise training in TFAM transgenic mice prior to HLS has a synergistic effect in ...
Theilen NT +3 more
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Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension [PDF]
Brazilian Journal of Medical and Biological Research, 2019 The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days.
G.N. Marzuca-Nassr +7 more
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The Oxidative Phosphorylation and Cytoskeleton Proteins of Mouse Ovaries after 96 Hours of Hindlimb Suspension [PDF]
Life, 2023 The purpose of this study was to assess oxidative phosphorylation (OXPHOS) in mouse ovaries, determine the relative content of proteins that form the respiratory chain complexes and the main structures of the cytoskeleton, and determine the mRNA of the ...
Elena Yu. Gorbacheva +3 more
doaj +3 more sources
FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension [PDF]
BMC Musculoskeletal Disorders, 2007 Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave +4 more
doaj +5 more sources
The Effects of Progressive Resistance Exercise on Recovery Rate of Bone and Muscle in a Rodent Model of Hindlimb Suspension [PDF]
Frontiers in Physiology, 2018 Purpose: This study aimed to examine the exercise-mediated musculoskeletal recovery following hindlimb suspension (HS) in order to identify whether bone modeling and muscle hypertrophy would eventuate in a synchronized manner during recovery stage ...
Hansol Song +6 more
doaj +3 more sources
Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections. [PDF]
PLoS ONE, 2014 A major risk of extended space travel is the combined effects of weightlessness and radiation exposure on the immune system. In this study, we used the hindlimb suspension model of microgravity that includes the other space stressors, situational and ...
Minghong Li +6 more
doaj +5 more sources
Time course of hepatic gluconeogenesis during hindlimb suspension unloading [PDF]
Experimental Physiology, 2012 New Findings What is the central question of this study?The rate of liver gluconeogenesis during hindlimb suspension unloading has not been determined. What is the main finding and its importance?Hepatic gluconeogenesis is significantly increased under conditions of hindlimb suspension unloading, which simulates the muscular atrophy occurring during ...
Ilya Bederman +4 more
openalex +4 more sources