Results 91 to 100 of about 492,458 (242)

Behavioral and Neurobiological Correlates of Resilience in the Hindlimb Unloading Mouse Model: A Longitudinal Ethogram with Neurotrophin Profile

Life
Among ground-based paradigms used to reproduce altered gravity exposure, the hindlimb unloading (HU) model is widely employed to simulate microgravity conditions by removing gravitational loading from the hindlimbs.
Arianna Racca, Patrizia Pignataro, Roberta Zerlotin, Graziana Esposito, Bijorn Omar Balzamino, Alessandra Micera, Maria Grano, Daniela Santucci   +7 more
doaj   +1 more source

Piezo‐type mechanosensitive cation channel 1 in bone biomechanics and its multidimensional distribution characteristics in skeletal tissue

VIEW, EarlyView.
PIEZO1 is highly correlated with mechanical stimulation, controlling bone growth and remodeling, while showing specific distribution characteristics under distinct loads. Upon dialectical review, this manuscript proposes that PIEZO1 could serve as a target for osteoporosis and a quantitative indicator for monitoring bone health in real‐time.
Chunyu Zhang, Yuehong Wang
wiley   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells

Cancer Science, EarlyView.
Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao, Xiaodan Wang, Chun‐Hui Jin, Zhifeng Wei, Qinghao Ding, Ke‐Ke Zhang, Bo‐Wen Dong, Kai‐Wen Zheng, Yufei Hou, Tao Zhang, Wen‐Jie Zhao, Zheng Hu, Yong‐Guang Yang   +12 more
wiley   +1 more source

Alterations in Muscle Mass and Contractile Phenotype in Response to Unloading Models: Role of Transcriptional/Pretranslational Mechanisms

Frontiers in Physiology, 2013
Skeletal muscle is the largest organ system in mammalian organisms providing postural control and movement patterns of varying intensity. Through evolution, skeletal muscle fibers have evolved into three phenotype clusters defined as a muscle unit which ...
Kenneth M Baldwin, Fadia eHaddad, Fadia eHaddad, Clay E Pandorf, Roland R Roy, Roland R Roy, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton   +9 more
doaj   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Effects of protein‐based supplementation and endurance training on muscle mass and mitochondrial enzyme activity in rats treated with hindlimb suspension

The FASEB Journal, 2017
The purpose of the study was to investigate the effect of endurance exercise training with or without protein‐based supplementation on muscle mass and mitochondrial enzyme activity in disuse skeletal muscle atrophy caused by hindlimb suspension (HS).
Ching‐Han Chen, Pei‐Ni Chen, Chia‐Ying Wu, Yan‐Ting Yang, Chung-Yu Chen, Yi-Hung Liao   +5 more
semanticscholar   +1 more source

Descriptive epidemiology of long‐term injuries in jump racing Thoroughbreds in Great Britain

Equine Veterinary Journal, EarlyView.
Abstract Background Race‐related injuries in horse racing, especially those requiring extended recovery, are a welfare concern and threaten the sport's social licence. Previous studies predominantly report on fatalities; however, serious non‐fatal musculoskeletal injuries often end horses' racing careers or have a high recurrence risk.
Sophia McDonald, Kristien L. P. Verheyen, Yu‐Mei Chang, Sarah E. Allen   +3 more
wiley   +1 more source

The effect of full‐limb flexion tests on static and dynamic muscle activity and locomotion asymmetry in owner‐sound horses

Equine Veterinary Journal, EarlyView.
Abstract Background Flexion tests are commonly used in equine locomotion examinations to identify underlying locomotor issues, yet their neuromuscular effects remain poorly understood. Response variability raises concerns about their clinical value in lameness assessments and pre‐purchase evaluations.
Marijke Jonkhart, Filipe M. Serra Bragança, Ineke H. Smit, Harold Brommer, Jozef J. M. Suskens   +4 more
wiley   +1 more source

Does ulnar curvature covary with locomotion and substrate use in cercopithecids?

Journal of Anatomy, EarlyView.
This study investigates ulnar curvature in cercopithecids in relation to locomotor behaviors, introducing an analysis of anteroposterior and mediolateral curvature, using geometric morphometric on 167 specimens (23 species). Although the two curvatures distinguish arboreal and terrestrial quadrupeds, their moderate covariation suggests that they ...
Nicolas Pappalardo, Laurent Pallas, Julian Karoui‐Canedo, Franck Guy, Guillaume Daver   +4 more
wiley   +1 more source