Results 91 to 100 of about 13,691 (275)

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice

Aging Cell, Volume 24, Issue 4, April 2025.
In females, estradiol deficiency is a major environmental factor contributing to the age‐associated effects on satellite cells. To assess cell‐intrinsic versus environmental regulation of satellite cells, we perform two transplantation experiments, Adult or Aged satellite cells transplanted into Adult recipients, and Adult satellite cells transplanted ...
Brian P. Sullivan, Alexie A. Larson, Ahmed S. Shams, Shawna L. McMillin, Mara C. Ebeling, Sydney Peng, Michael Kyba, Dawn A. Lowe   +7 more
wiley   +1 more source

Publications of the space physiology and countermeasures program, Musculoskeletal Discipline: 1980-1990 [PDF]

A 10-year cumulative bibliography of publications resulting from research supported by the musculoskeletal discipline of the space physiology and countermeasures program of NASA's Life Sciences Division is provided.
Dickson, Katherine J., Hess, Elizabeth L., Powers, Janet V., Wallace-Robinson, Janice   +3 more
core   +1 more source

From Clinical to Benchside: Lacticaseibacillus and Faecalibacterium Are Positively Associated With Muscle Health and Alleviate Age‐Related Muscle Disorder

Aging Cell, Volume 24, Issue 5, May 2025.
Old people with or without sarcopenia exhibited different gut microbiota and metabolite compositions. Mice receiving microbes from people with sarcopenia displayed lower muscle mass and strength compared with those receiving microbes from non‐sarcopenic donors.
Chaoran Liu, Pui Yan Wong, Nilakshi Barua, Baoqi Li, Hei Yuet Wong, Ning Zhang, Simon Kwoon Ho Chow, Sunny Hei Wong, Jun Yu, Margaret Ip, Wing Hoi Cheung, Gustavo Duque, Christoph Brochhausen, Joseph Jao Yiu Sung, Ronald Man Yeung Wong   +14 more
wiley   +1 more source

Disuse histological changes of an unloading environment on joint components in rat knee joints

Osteoarthritis and Cartilage Open, 2019
Summary: Objectives: To clarify the effects of mechanical unloading on joint components, including the articular cartilage by knee compartments, synovial membrane, and the infrapatellar fat pad (IFP), using a hindlimb suspension rat model.
Ikufumi Takahashi, Taro Matsuzaki, Hiroshi Kuroki, Masahiro Hoso   +3 more
doaj  

Histological Analysis of the Effect of a Vector Potential Generator on the Femur of a Hindlimb-Suspended Rat

Anatomia
Disuse osteoporosis occurs due to rest and reduced mechanical stimulation. Under these conditions, bone resorption exceeds bone formation, leading to a decrease in bone density.
Wataru Minamizono, Nao Yashima, Hiroya Matsunaga, Kaoru Fujikawa, Hirai Suito, Takumi Okunuki, Masafumi Ohsako   +6 more
doaj   +1 more source

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation

Aging Cell, EarlyView.
This study identifies a macrophage subpopulation, Mac_1, that promotes skeletal muscle regeneration by enhancing muscle stem cell proliferation through HGF/MET signaling. A 3D‐muscle organoid model confirmed the critical role of HGF/MET signaling in regeneration, highlighting a potential therapeutic target for age‐related impairment of skeletal muscle ...
Hiroyuki Koike, Miho Sugimura, Rie Ouchi, Yuki Yoshimoto, Ichiro Manabe, Yumiko Oishi   +5 more
wiley   +1 more source

Responses of skeletal muscle to unloading, a review [PDF]

Suspension models were used to study muscle response to reduced activity. During 6 days of tail casting, the soleus (SOL) atrophies while the extensor digitorum longus grows relatively normally.
Henriksen, E. J., Jacob, S., Jaspers, S. R., Tischler, M. E.   +3 more
core   +1 more source

Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart

Aging Cell, EarlyView.
Exercise improves cardiac lymphatic architecture and function in the aged mouse. Aged hearts show reduced lymphatic vascular density, more dilated vessels, and increased peri‐lymphatic inflammation and fibrosis. Exercise training of the aged mouse increases lymph vessel density and sprouting, reverses their dilation, reduces inflammation and fibrosis ...
Kangsan Roh, Haobo Li, Rebecca Nicole Freeman, Luca Zazzeron, Ahlim Lee, Charles Zhou, Siman Shen, Peng Xia, Justin Ralph Baldovino Guerra, Cedric Sheffield, Timothy P. Padera, Yirong Zhou, Sekeun Kim, Aaron Aguirre, Nicolas Houstis, Jason D. Roh, Fumito Ichinose, Rajeev Malhotra, Anthony Rosenzweig, James Rhee   +19 more
wiley   +1 more source

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source