Results 101 to 110 of about 13,691 (275)

Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading

Bioscience Journal, 2012
We investigated the importance of daily free activity in the cage and body weight gain during the recovering of bone structural and mechanical properties in growing rats after hindlimb unloading. Eight-week-old male Wistar rats were randomly divided into
Adelton Andrade Barbosa, Ricardo Junqueira Del Carlo, Simone Rezende Galvão, Mário Jefferson Quirino Louzada, Frederico Souzalima Caldoncelli Franco, Bárbara Braga Fernandes, Miguel Araújo Carneiro-Junior, Regiane Maria Soares Ramos, Lucas Rios Drummond, Antonio Jose Natali   +9 more
doaj  

The mERG1a channel modulates skeletal muscle MuRF1, but not MAFbx, expression. [PDF]

, 2013
INTRODUCTION: We investigated the mechanism by which the MERG1a K+ channel increases ubiquitin proteasome proteolysis (UPP). METHODS: Hindlimb suspension and electro-transfer of Merg1a cDNA into mouse gastrocnemius muscles induced atrophy.
Bradley, Kevin S, Du, Huahua, Fujita, Naoya, Hannon, Kevin M, Hockerman, Gregory H, Jaeger, Christine, Nedele, Carrie, Pond, Amber L, Walther, Claire, Wang, Wen-Horng, Wang, Xun   +10 more
core   +2 more sources

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension [PDF]

Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly,
Henriksen, E. J., Jacob, S., Jaspers, S. R., Tischler, M. E.   +3 more
core   +1 more source

Limb bone scaling in hopping diprotodonts and quadrupedal artiodactyls [PDF]

Bone adaptation is modulated by the timing, direction, rate, and magnitude of mechanical loads. To investigate whether frequent slow, or infrequent fast, gaits could dominate bone adaptation to load, we compared scaling of the limb bones from two ...
Chua, M Y, Doube, M, Felder, A A, Hutchinson, J R, Klosowski, M M, Lodhia, K, Shefelbine, S J   +6 more
core   +1 more source

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Antoni L. Andreu, Elizabeth M. C. Fisher, Francesca Achilli, Gareth T. Banks, Hazel P. Williams, J. Barney Bryson, Linda Greensmith, Ruth Chia, Virginie Bros-Facer   +8 more
core   +4 more sources

Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications

Brain Pathology, EarlyView.
Elevated angiogenin levels in skeletal muscle are linked to slower disease progression, enhanced regeneration, and vascularization through satellite‐endothelial interaction during myogenesis in ALS. Angiogenin and its tiRNAs may serve as prognostic markers and therapeutic targets for ALS.
Paola Fabbrizio, Sharada Baindoor, Cassandra Margotta, Junyi Su, Elena P. Morrissey, Ina Woods, Marion C. Hogg, Sara Vianello, Morten T. Venø, Jørgen Kjems, Gianni Sorarù, Caterina Bendotti, Jochen H. M. Prehn, Giovanni Nardo   +13 more
wiley   +1 more source

Protective effect of the Quercetin on experimental cuprizone-induced multiple sclerosis in male C57BL/6 mice

Current Research in Physiology
This study aimed to determine protective effect of the Quercetin on experimental cuprizone-induced (CPZ) multiple sclerosis (MS) in Male C57BL/6 mice. Forty male C57BL/6 mice were allocated into 4 experimental groups.
Samin Ghasemi, Shahin Hassanpour, Razieh Hosseini   +2 more
doaj  

Alterations in Muscle Mass and Contractile Phenotype in Response to Unloading Models: Role of Transcriptional/Pretranslational Mechanisms

Frontiers in Physiology, 2013
Skeletal muscle is the largest organ system in mammalian organisms providing postural control and movement patterns of varying intensity. Through evolution, skeletal muscle fibers have evolved into three phenotype clusters defined as a muscle unit which ...
Kenneth M Baldwin, Fadia eHaddad, Fadia eHaddad, Clay E Pandorf, Roland R Roy, Roland R Roy, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton   +9 more
doaj   +1 more source

Cinnamtannin A2, (-)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension. [PDF]

J Clin Biochem Nutr, 2023
Muta O, Oyama S, Odaka M, Shimizu K, Katsuragawa S, Suzuki K, Fushimi T, Fujii Y, Akagi R, Osakabe N.   +9 more
europepmc   +1 more source