Results 111 to 120 of about 13,691 (275)
Experiment K-6-10. Effects of zero gravity on myofibril protein content and isomyosin distribution in rodent skeletal muscle [PDF]
The purpose of this experiment was to investigate the effects of 12 days of zero gravity (0G) exposure (Cosmos 1887 Biosputnik) on the enzymatic properties, protein content, and isomyosin distribution of the myofibril fraction of the slow-twitch vastus ...
Baldwin, K., Herrick, R., Oganov, V.
core +1 more source
Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats [PDF]
, 2015 BACKGROUND: Calcitriol is documented to cause significant increase in bone mass densitometry counteracting osteoporosis. Promising results of calcitriol supplementation in studies aiming space flight induced osteoporosis is little and the effect of this ...
Amir Khoshvaghti +4 more
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British Journal of Pharmacology, Volume 182, Issue 9, Page 2014-2030, May 2025.Abstract Background and Purpose Sphingosine‐1‐phosphate (S1P) receptor modulator (SRM) drugs suppress immune system function by disrupting lymphocyte trafficking, but SRMs are broadly immunosuppressive with on‐target liabilities. Another strategy to modulate the immune system is to block S1P transport.
Yugesh Kharel +17 more
wiley +1 more source
Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. [PDF]
, 2017 Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies ...
Verkman, Alan S, Yao, Xiaoming
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MUSTN1 Interaction With SMPX Regulates Muscle Development and Regeneration
Cell Proliferation, EarlyView.Model of the role of MUSTN1 in skeletal muscle development. MUSTN1‐KO mice display delayed muscle growth and regeneration. MUSTN1 protects SMPX from instability and maintains the morphology of muscle fibres. MUSTN1 and SMPX synergistically promote myoblast proliferation and dependently facilitate differentiation.
Yu Fu +6 more
wiley +1 more source
Digital Chinese Medicine, 2023 Objective: To explore the therapeutic effects of ginseng total saponins (GTSs) on cognitive impairments in astronauts caused by prolonged exposure to microgravity environment.
Dong Lijinchuan +8 more
doaj
Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension. [PDF]
Cartilage, 2023 Takahashi I +3 more
europepmc +1 more source
Cell Proliferation, EarlyView.TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. ABSTRACT Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that
Tianlun Zhao +6 more
wiley +1 more source
PLoS ONE, 2019 Mechanical loading is essential for the maintenance of musculoskeletal homeostasis. Cartilage has been demonstrated to be highly mechanoresponsive, but the mechanisms by which chondrocytes respond to mechanical stimuli are not clearly understood.
Rachel C Nordberg +4 more
doaj +1 more source
Musculoskeletal discipline science plan [PDF]
Life sciences research in the musculoskeletal discipline must identify possible consequences of weightlessness on this system, understand the mechanisms of these effects, and develop effective and operationally practical countermeasures to protect ...
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