Results 121 to 130 of about 492,458 (242)

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Alteration of vasopressin-aquaporin system in hindlimb unloading mice

Frontiers in Physiology
Murine hindlimb unloading (HU) is considered a model of choice for simulating the physiological effects of microgravity on several functions, including fluid and electrolyte homeostasis.
Marianna Ranieri, Maria Venneri, Giuseppina Storlino, Angela Ferrulli, Mariagrazia D’Agostino, Mariangela Centrone, Annarita Di Mise, Annarita Di Mise, Roberta Zerlotin, Grazia Tamma, Maria Grano, Giovanna Valenti   +11 more
doaj   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

A New Experimental Protocol for Assessing Hominoid Assisted Arboreal Bipedalism

American Journal of Biological Anthropology, Volume 189, Issue 1, January 2026.
A new experimental protocol for investigating arboreal bipedalism in hominoids was successfully used by all available age and sex classes of chimpanzees in the case study. This protocol identifies two forms of arboreal bipedalism: forward facing and sideways, and allows for the collection of gait parameter data for future comparative studies.
Victoria A. Lockwood, François Druelle, Alicia Blasi‐Toccacceli, Jean‐Pascal Guéry, Guillaume Daver   +4 more
wiley   +1 more source

Cortically Dependent Motor Training Does Not Induce Abnormal Movements in DYT1‐Knock In Mice

Brain and Behavior, Volume 16, Issue 1, January 2026.
DYT1 dystonia is a familial autosomal dominant, childhood onset dystonia. Mouse models recapitulating the human genotype do not exhibit overtly dystonic movements. It is unclear whether cortically‐dependent tasks are necessary for the development of dystonic movements.
Alexander T. Hodge, Mohammed A. Rasheed, Tiffany Lin, Christian R. Burgess, Daniel K. Leventhal   +4 more
wiley   +1 more source

Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension

, 2019
Gabriel Nasri Marzuca-Nassr, Marco Aurélio Salomão Fortes, Lucas Guimarães‐Ferreira, Gilson Masahiro Murata, Kaio F. Vitzel, Diogo Antônio Alves de Vasconcelos, Reinaldo Abunasser Bassit, Rui Curi   +7 more
openalex   +1 more source

MAFG Induces the Methylation of CRYAB to Promote the Activation of A1 Astrocyte After Spinal Cord Injury

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
All in all, silencing MAFG inhibited the activation of A1 astrocyte and neuroinflammation through regulating CRYAB methylation. ABSTRACT Purpose To investigate the effects of MAF bZIP transcription factor G (MAFG) on the transformation of A1/A2 reactive astrocytes and the production of inflammatory factors after spinal cord injury (SCI). Methods An SCI
Xuefei Li, Zhuang Zhu, Ying Wang, Hao Wan, Zhiwei Wang, Wanqing Qiao   +5 more
wiley   +1 more source

Polydopamine‐Based Antioxidant Countermeasures Against Spaceflight‐Induced Neurodegeneration

Small Science, Volume 6, Issue 1, January 2026.
Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Alessio Carmignani, Attilio Marino, Matteo Battaglini, Melike Belenli Gümüş, Elisa Carrubba, Michele Balsamo, Giovanni Valentini, Gabriele Mascetti, Marco Vukich, Giada Graziana Genchi, Gianni Ciofani   +10 more
wiley   +1 more source

Freshwater amphibians and squamates from Villeveyrac (lower Campanian; Hérault, France): palaeodiversity, palaeoenvironment and implications for the Late Cretaceous palaeobiogeography of the European herpetofauna

Papers in Palaeontology, Volume 12, Issue 1, January/February 2026.
Abstract The Late Cretaceous witnessed numerous transgression–regression sequences and the onset of a global cooling phase at the start of the Campanian. In the European archipelago, these environmental changes, combined with active plate tectonics, facilitated the formation of ephemeral land bridges that served as dispersal routes for a variety of ...
Olivier Jansen, Géraldine Garcia, Olga Otero, Marc Augé, Bernard Gomez, Xavier Valentin   +5 more
wiley   +1 more source

Effects of Postmortem Aging on Nutritional Quality and Myofibrillar Protein Function in Bactrian Camel Meat

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT This study investigated the effects of postmortem aging on the nutritional quality and physicochemical properties of myofibrillar proteins (MFP) in Bactrian camel meat. In this study, hindlimb meat from five Bactrian camels was aged at 4°C and sampled on D0, D1, D3, D5, and D7.
Gai Hang, Liang Ming, Rendalai Si
wiley   +1 more source